丘脑底核深部脑刺激术后的总电能（TEED）能否改变帕金森病患者的言语流畅性？一项初步证据。
Can total electrical energy (TEED) after subthalamic DBS alter verbal fluency in Parkinson's disease patients? A preliminary evidence.
作者信息
Ruggiero Fabiana, Mameli Francesca, Aiello Edoardo Nicolò, Zirone Eleonora, Cogiamanian Filippo, Borellini Linda, Pirola Elena, Ampollini Antonella, Poletti Barbara, De Sandi Angelica, Prenassi Marco, Marceglia Sara, Ticozzi Nicola, Silani Vincenzo, Locatelli Marco, D'Urso Giordano, Barbieri Sergio, Priori Alberto, Ferrucci Roberta
机构信息
Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan20122, Italy.
Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Milan20149, Italy.
出版信息
CNS Spectr. 2024 Oct 28:1-4. doi: 10.1017/S1092852924000439.
OBJECTIVE
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) improves motor outcomes in Parkinson's disease (PD) but may have adverse long-term effects on specific cognitive domains. The aim of this study was to investigate the association between total electrical energy (TEED) delivered by DBS and postoperative changes in verbal fluency.
METHODS
Seventeen PD patients undergoing bilateral STN-DBS were assessed with the Alternate Verbal Fluency Battery (AVFB), which includes phonemic (PVF), semantic (SVF), and alternate verbal fluency (AVF) tests, before surgery (T0) and after 6 (T1) and 12 months (T2). Bilateral TEED and average TEEDM were recorded at T1 and T2. For each AVFB measurement, changes from T0 to T1 (Δ-01) and from T0 to T2 (Δ-02) were calculated.
RESULTS
At T1, PVF ( = 0.007) and SVF scores ( = 0.003) decreased significantly. TEED measures at T1 and T2 were unrelated to Δ-01 and Δ-02 scores, respectively. However, an inverse, marginally significant association was detected between the TEEDM and Δ-01 scores for the AVF ( = 0.041, against an α = 0.025).
CONCLUSIONS
In conclusion, the present reports provide preliminary evidence that TEED may not be responsible or only slightly responsible for the decline in VF performance after STN-DBS in PD.
目的
丘脑底核（STN）的深部脑刺激（DBS）可改善帕金森病（PD）的运动结局，但可能对特定认知领域产生长期不良影响。本研究旨在探讨DBS传递的总电能（TEED）与术后语言流畅性变化之间的关联。
方法
对17例接受双侧STN-DBS的PD患者在手术前（T0）、术后6个月（T1）和12个月（T2）使用交替语言流畅性测试组（AVFB）进行评估，该测试组包括音素（PVF）、语义（SVF）和交替语言流畅性（AVF）测试。在T1和T2记录双侧TEED和平均TEEDM。对于每次AVFB测量，计算从T0到T1（Δ-01）和从T0到T2（Δ-02）的变化。
结果
在T1时，PVF（ = 0.007）和SVF分数（ = 0.003）显著下降。T1和T2时的TEED测量值分别与Δ-01和Δ-02分数无关。然而，检测到TEEDM与AVF的Δ-01分数之间存在反向的、边缘显著的关联（ = 0.041，α = 0.025）。
结论
总之，本报告提供了初步证据，表明TEED可能不是PD患者STN-DBS后VF性能下降的原因，或仅在轻微程度上是其原因。
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