临床设定的液压密封剂与不同根管干燥方案和封闭技术联合使用的离体评估：一项随机临床试验。

Ex-vivo evaluation of clinically-set hydraulic sealers used with different canal dryness protocols and obturation techniques: a randomized clinical trial.

机构信息

Department of Endodontics, Faculty of Dentistry, The British University in Egypt (BUE), 24 Hasan Elgamal street El Sherouk City, Nasr City, Cairo, 11837, Egypt.

Department of Endodontics, Faculty of Dentistry, Ain Shams University, Cairo, 11566, Egypt.

出版信息

Clin Oral Investig. 2024 Oct 27;28(11):612. doi: 10.1007/s00784-024-06006-5.

DOI:10.1007/s00784-024-06006-5

PMID:39463194

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11513728/

Abstract

OBJECTIVES

This 2-part randomized parallel triple-blind clinical trial adopts a unique model assessing clinically-set hydraulic calcium silicate-based sealers (HCSBS) after different root canal dryness protocols and obturation techniques.

METHODS

For the first phase of the study, 24 teeth scheduled for orthodontic extractions were allocated into four groups according to the canal dryness protocol and the obturation technique. G1 (CLC-AHP): cold lateral compaction (CLC) with AH Plus sealer, G2 (CLC-ES-SD): CLC with Endosequence (ES) after standard canal(s) dryness (SD); G3 (SC-ES-SD): matching single-cone (SC) with ES after SD; G4 (SC-ES-PD): as G3 but after partial canal(s) dryness (PD). Teeth were extracted after one month of clinical service and examined for intracanal voids by micro-CT (2D & 3D). For the 2nd phase, another 24 teeth were allocated into four groups according to the root canal dryness protocol and the HCSBS used (ES or CeraSeal (CeS)). Teeth were extracted after one month and sectioned vertically for energy dispersive X-ray (EDX)/scanning electron microscope (SEM) examination. One-way ANOVA with Games-Howell post-hoc test and Chi-square test with multiple z-tests were used for statistical analysis.

RESULTS

SC-PD showed the highest percentage of voids (p < 0.05). MicroCT scans as well as EDX/SEM examination showed that PD resulted in significantly larger interfacial gaps (p < 0.001) with more hydration products at the sealer/dentin interface than SD.

CONCLUSIONS

Both tested dryness protocols allowed the hydration of HCSBS and the formation of hydration products, thus standard dryness is recommended to reduce the incidence of intracanal voids.

CLINICAL RELEVANCE

When using the single-cone obturation technique, intentional root canal moisture negatively affects the performance of HCSBS.

PROTOCOL REGISTRATION

http://www.

CLINICALTRIALS

gov, ID: NCT05808062.

摘要

目的

本随机平行双盲临床试验分两部分进行，采用独特的模型评估临床设定的水基硅酸钙基密封剂（HCSBS）在不同根管干燥方案和封闭技术后的效果。

方法

在研究的第一阶段，根据根管干燥方案和封闭技术，将 24 颗计划正畸拔牙的牙齿分为四组。G1（CLC-AHP）：冷侧压（CLC）加 AH Plus 密封剂，G2（CLC-ES-SD）：CLC 加 Endosequence（ES）后标准干燥（SD）；G3（SC-ES-SD）：与 ES 匹配的单尖（SC）后 SD；G4（SC-ES-PD）：与 G3 相同，但为部分干燥（PD）。一个月的临床服务后，将牙齿拔出，用微 CT（2D 和 3D）检查根管内的空隙。第二阶段，根据根管干燥方案和使用的 HCSBS（ES 或 CeraSeal（CeS）），将另外 24 颗牙齿分为四组。一个月后，将牙齿垂直切开，进行能量色散 X 射线（EDX）/扫描电子显微镜（SEM）检查。采用单因素方差分析（One-way ANOVA）和 Games-Howell 事后检验以及卡方检验（Chi-square test）和多重 z 检验进行统计学分析。