Department of Internal Medicine, Punjab Medical College, 38000 Faisalabad, Punjab, Pakistan.
Department of Internal Medicine, Dow Medical College, 74200 Karachi, Sindh, Pakistan.
Discov Med. 2024 Oct;36(189):1973-1986. doi: 10.24976/Discov.Med.202436189.182.
This article explores the correlation between vitamin D levels and cardiovascular health, focusing on hypertension, atherosclerosis, and cardiac dysfunction. Cardiovascular diseases (CVDs) rank as the leading global cause of death, underscoring the significance of exploring vitamin D's potential role in maintaining a healthy cardiovascular system. It discusses vitamin D's mechanisms of action, including genomic and non-genomic pathways, and explores risk factors like smoking, obesity, and hypertension, linked to vitamin D deficiency. Additionally, it delves into its role in regulating the renin-angiotensin system, cardiac hypertrophy, and inflammation. The link between vitamin D supplementation and a lower risk of cardiovascular events, including hypertension, atherosclerosis, and heart failure, is considered. However, inconsistent results from supplementation trials call for further research to establish efficacy for cardiovascular health. In conclusion, the article emphasizes the importance of vitamin D for cardiovascular well-being and calls for comprehensive studies to explore its therapeutic potential in treating cardiovascular disease (CVD).
本文探讨了维生素 D 水平与心血管健康之间的相关性，重点关注高血压、动脉粥样硬化和心功能障碍。心血管疾病（CVD）是全球主要的死亡原因，这突显了探索维生素 D 在维持健康心血管系统中潜在作用的重要性。文中讨论了维生素 D 的作用机制，包括基因组和非基因组途径，并探讨了与维生素 D 缺乏相关的风险因素，如吸烟、肥胖和高血压。此外，还研究了维生素 D 在调节肾素-血管紧张素系统、心肌肥厚和炎症中的作用。文中还考虑了维生素 D 补充与降低心血管事件风险（包括高血压、动脉粥样硬化和心力衰竭）之间的联系。然而，补充试验的结果不一致，需要进一步研究以确定其对心血管健康的疗效。总之，本文强调了维生素 D 对心血管健康的重要性，并呼吁开展全面研究，以探索其在治疗心血管疾病（CVD）方面的治疗潜力。
