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妊娠期常见可变型低丙种球蛋白血症:大剂量免疫球蛋白输注治疗

Common variable hypogammaglobulinemia in pregnancy: treatment with high-dose immunoglobulin infusions.

作者信息

Madsen D L, Catanzarite V A, Varela-Gittings F

出版信息

Am J Hematol. 1986 Mar;21(3):327-9. doi: 10.1002/ajh.2830210313.

DOI:10.1002/ajh.2830210313
PMID:3946412
Abstract

Pregnancy outcomes when the mother has common variable hypogammaglobulinemia are poor unless immunoglobulin levels are returned to normal or near-normal range. Intravenous immunoglobulin infusions are the favored mode of therapy. Here, we report the fifth patient so treated. Weekly doses of 200 mg/kg during the third trimester were required. A healthy term baby was delivered and the postpartum course was uncomplicated.

摘要

当母亲患有常见变异型低丙种球蛋白血症时,除非免疫球蛋白水平恢复到正常或接近正常范围,否则妊娠结局不佳。静脉注射免疫球蛋白是首选的治疗方式。在此,我们报告第五例接受该治疗的患者。孕晚期需要每周给予200mg/kg的剂量。产妇顺利分娩出一名健康足月儿,产后过程无并发症。

相似文献

1
Common variable hypogammaglobulinemia in pregnancy: treatment with high-dose immunoglobulin infusions.妊娠期常见可变型低丙种球蛋白血症:大剂量免疫球蛋白输注治疗
Am J Hematol. 1986 Mar;21(3):327-9. doi: 10.1002/ajh.2830210313.
2
Intravenous immunoglobulin in pregnancy.孕期静脉注射免疫球蛋白
Obstet Gynecol. 1985 Sep;66(3 Suppl):39S-40S.
3
Use of intravenous immune globulin in pregnant women with common variable hypogammaglobulinemia.
Am J Med. 1984 Mar 30;76(3A):73-7. doi: 10.1016/0002-9343(84)90323-1.
4
Intravenous immune serum globulin replacement in hypogammaglobulinemia. A comparison of high- versus low-dose therapy.
Monogr Allergy. 1988;23:177-86.
5
High-dose immunoglobulin replacement therapy by slow subcutaneous infusion during pregnancy.孕期通过皮下缓慢输注进行大剂量免疫球蛋白替代治疗。
JAMA. 1982 May 28;247(20):2824-5.
6
Common variable hypogammaglobulinemia. A case report.普通变异型低丙种球蛋白血症。病例报告。
J Clin Gastroenterol. 1990 Jun;12(3):336-40. doi: 10.1097/00004836-199006000-00023.
7
[Variable immune deficiency syndrome with antibody deficiency--long-term substitution with immunoglobulins].
Immun Infekt. 1984 Apr;12(2):123-8.
8
Intramuscular and intravenous administration of immunoglobulin to patients with hypogammaglobulinemia.对低丙种球蛋白血症患者进行免疫球蛋白的肌肉注射和静脉注射。
Birth Defects Orig Artic Ser. 1983;19(3):205-7.
9
Intravenous gamma-globulin in pregnancy: a review.孕期静脉注射丙种球蛋白:综述
Obstet Gynecol Surv. 1989 Jan;44(1):25-34. doi: 10.1097/00006254-198901000-00003.
10
Slow subcutaneous immunoglobulin therapy in a patient with reactions to intramuscular immunoglobulin.
J Clin Immunol. 1983 Jul;3(3):285-6. doi: 10.1007/BF00915353.

引用本文的文献

1
Pregnancy Outcome in Patients with Common Variable Immunodeficiency.普通可变免疫缺陷患者的妊娠结局
J Clin Immunol. 2015 Aug;35(6):531-7. doi: 10.1007/s10875-015-0188-7. Epub 2015 Aug 18.
2
Fertility, pregnancies and outcomes reported by females with common variable immune deficiency and hypogammaglobulinemia: results from an internet-based survey.常见可变免疫缺陷和低丙种球蛋白血症女性的生育力、妊娠情况及结局:一项基于互联网调查的结果
J Clin Immunol. 2015 Feb;35(2):125-34. doi: 10.1007/s10875-014-0123-3. Epub 2015 Jan 9.
3
Rapid subcutaneous IgG replacement therapy at home for pregnant immunodeficient women.
居家对妊娠免疫缺陷妇女进行快速皮下注射免疫球蛋白替代疗法。
J Clin Immunol. 2001 Mar;21(2):150-4. doi: 10.1023/a:1011051704960.
4
Intravenous immunoglobulin replacement therapy for common variable immunodeficiency during pregnancy.孕期普通变异型免疫缺陷的静脉注射免疫球蛋白替代疗法。
Arch Gynecol Obstet. 1996;258(3):155-9. doi: 10.1007/s004040050118.
5
IgG replacement therapy for primary hypogammaglobulinaemia during pregnancy: report of 9 pregnancies in 4 patients.孕期原发性低丙种球蛋白血症的IgG替代疗法:4例患者9次妊娠的报告
Blut. 1990 Mar;60(3):198-201. doi: 10.1007/BF01720276.