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孕期原发性低丙种球蛋白血症的IgG替代疗法：4例患者9次妊娠的报告

IgG replacement therapy for primary hypogammaglobulinaemia during pregnancy: report of 9 pregnancies in 4 patients.

作者信息

Williams P E, Leen C L, Heppleston A D, Yap P L

机构信息

Blood Transfusion Centre, Royal Infirmary, Edinburgh, UK.

出版信息

Blut. 1990 Mar;60(3):198-201. doi: 10.1007/BF01720276.

DOI:10.1007/BF01720276
PMID:2317569
Abstract

We report the cases of four pregnant women with primary hypogammaglobulinaemia, who received intramuscular, intravenous or no replacement therapy with IgG in late pregnancy, and review the literature. Intravenous replacement administered to the mother during pregnancy produces adequate serum IgG levels in the neonate, and should be the treatment of choice in this situation.

摘要

我们报告了4例原发性低丙种球蛋白血症孕妇的病例，她们在妊娠晚期接受了肌内、静脉注射免疫球蛋白替代治疗或未接受替代治疗，并对相关文献进行了综述。孕期对母亲进行静脉替代治疗可使新生儿血清免疫球蛋白G水平充足，在这种情况下应作为首选治疗方法。

相似文献

1
IgG replacement therapy for primary hypogammaglobulinaemia during pregnancy: report of 9 pregnancies in 4 patients.孕期原发性低丙种球蛋白血症的IgG替代疗法：4例患者9次妊娠的报告
Blut. 1990 Mar;60(3):198-201. doi: 10.1007/BF01720276.
2
An evaluation of the safety of three intravenous immunoglobulin preparations in patients with primary hypogammaglobulinaemia.三种静脉注射免疫球蛋白制剂用于原发性低丙种球蛋白血症患者的安全性评估。
J Infect. 1986 Jan;12(1):5-10. doi: 10.1016/s0163-4453(86)94717-1.
3
Use of intravenous immune globulin in pregnant women with common variable hypogammaglobulinemia.
Am J Med. 1984 Mar 30;76(3A):73-7. doi: 10.1016/0002-9343(84)90323-1.
4
[Idiopathic autoimmune thrombopenic purpura and pregnancy].
Nouv Rev Fr Hematol (1978). 1987;29(6):401-5.
5
Penetration of administered IgG into the maxillary sinus and long-term clinical effects of intravenous immunoglobulin replacement therapy on sinusitis in primary hypogammaglobulinaemia.静脉注射免疫球蛋白替代疗法中给予的免疫球蛋白在上颌窦的渗透情况及其对原发性低丙种球蛋白血症患者鼻窦炎的长期临床疗效。
Acta Otolaryngol. 1991;111(3):550-5. doi: 10.3109/00016489109138382.
6
High-dose intravenous IgG before delivery of idiopathic thrombocytopenic purpura: transplacental treatment of the fetus.
Nihon Ketsueki Gakkai Zasshi. 1987 Jul;50(4):890-4.
7
Common variable hypogammaglobulinemia in pregnancy.妊娠期间的常见变异型低丙种球蛋白血症。
Br J Obstet Gynaecol. 1993 Dec;100(12):1138-40. doi: 10.1111/j.1471-0528.1993.tb15181.x.
8
Immunologic maturation in an infant born to a mother with agammaglobulinemia.患有无丙种球蛋白血症的母亲所生婴儿的免疫成熟情况。
Am J Dis Child. 1980 Oct;134(10):942-4. doi: 10.1001/archpedi.1980.02130220020006.
9
Serum ALT levels in patients with primary hypogammaglobulinaemia receiving replacement therapy with intravenous immunoglobulin or fresh frozen plasma.接受静脉注射免疫球蛋白或新鲜冷冻血浆替代治疗的原发性低丙种球蛋白血症患者的血清谷丙转氨酶水平。
Vox Sang. 1986;50(1):26-32. doi: 10.1111/j.1423-0410.1986.tb04841.x.
10
[Prenatal treatment of alloimmune thrombocytopenia using high-dosage IgG].[使用高剂量免疫球蛋白进行同种免疫性血小板减少症的产前治疗]
Ned Tijdschr Geneeskd. 1993 Feb 20;137(8):416-9.

引用本文的文献

1
Pregnancy complications in women with an inborn error of immunity: a systematic review.免疫缺陷病女性的妊娠并发症：一项系统评价
Curr Opin Allergy Clin Immunol. 2025 Dec 1;25(6):464-477. doi: 10.1097/ACI.0000000000001122. Epub 2025 Oct 24.
2
II Brazilian Consensus on the use of human immunoglobulin in patients with primary immunodeficiencies.二、巴西关于原发性免疫缺陷患者使用人免疫球蛋白的共识
Einstein (Sao Paulo). 2017;15(1):1-16. doi: 10.1590/S1679-45082017AE3844.
3
Pregnancy Outcome in Patients with Common Variable Immunodeficiency.

本文引用的文献

1
The morphologic basis of antibody formation development during the neonatal period.新生儿期抗体形成发育的形态学基础。
J Lab Clin Med. 1959 Mar;53(3):331-57.
2
High-dose immunoglobulin replacement therapy by slow subcutaneous infusion during pregnancy.孕期通过皮下缓慢输注进行大剂量免疫球蛋白替代治疗。
JAMA. 1982 May 28;247(20):2824-5.
3
Primary hypogammaglobulinaemia: impaired lung function and body growth with delayed diagnosis and inadequate treatment.原发性低丙种球蛋白血症：肺功能和身体生长受损，诊断延迟且治疗不足。
普通可变免疫缺陷患者的妊娠结局
J Clin Immunol. 2015 Aug;35(6):531-7. doi: 10.1007/s10875-015-0188-7. Epub 2015 Aug 18.
4
Fertility, pregnancies and outcomes reported by females with common variable immune deficiency and hypogammaglobulinemia: results from an internet-based survey.常见可变免疫缺陷和低丙种球蛋白血症女性的生育力、妊娠情况及结局：一项基于互联网调查的结果
J Clin Immunol. 2015 Feb;35(2):125-34. doi: 10.1007/s10875-014-0123-3. Epub 2015 Jan 9.
5
Rapid subcutaneous IgG replacement therapy at home for pregnant immunodeficient women.居家对妊娠免疫缺陷妇女进行快速皮下注射免疫球蛋白替代疗法。
J Clin Immunol. 2001 Mar;21(2):150-4. doi: 10.1023/a:1011051704960.
6
Intravenous immunoglobulin replacement therapy for common variable immunodeficiency during pregnancy.孕期普通变异型免疫缺陷的静脉注射免疫球蛋白替代疗法。
Arch Gynecol Obstet. 1996;258(3):155-9. doi: 10.1007/s004040050118.
Eur J Respir Dis. 1984 Oct;65(7):529-36.
4
Use of intravenous immune globulin in pregnant women with common variable hypogammaglobulinemia.
Am J Med. 1984 Mar 30;76(3A):73-7. doi: 10.1016/0002-9343(84)90323-1.
5
Gamma globulin therapy during pregnancy in mother with hypogammaglobulinemia.孕期对患有低丙种球蛋白血症的母亲进行丙种球蛋白治疗。
Am J Obstet Gynecol. 1982 Sep 1;144(1):112. doi: 10.1016/0002-9378(82)90408-2.
6
Hypogammaglobulinaemia during pregnancy in identical twin sisters.同卵双胞胎姐妹孕期的低丙种球蛋白血症。
Int J Gynaecol Obstet. 1982 Dec;20(6):471-3. doi: 10.1016/0020-7292(82)90008-x.
7
Immunological maturation in an infant of an agammaglobulinaemic mother.无丙种球蛋白血症母亲所生婴儿的免疫成熟
Lancet. 1966 Nov 26;2(7474):1152-5. doi: 10.1016/s0140-6736(66)90473-9.
8
Intravenous immunoglobulin in pregnancy.孕期静脉注射免疫球蛋白
Obstet Gynecol. 1985 Sep;66(3 Suppl):39S-40S.
9
Common variable hypogammaglobulinemia in pregnancy: treatment with high-dose immunoglobulin infusions.妊娠期常见可变型低丙种球蛋白血症：大剂量免疫球蛋白输注治疗
Am J Hematol. 1986 Mar;21(3):327-9. doi: 10.1002/ajh.2830210313.
10
Increase of serum immunoglobulin level into the normal range in primary hypogammaglobulinaemia by dosage individualization of intravenous immunoglobulin.通过静脉注射免疫球蛋白剂量个体化使原发性低丙种球蛋白血症患者血清免疫球蛋白水平升至正常范围
Vox Sang. 1986;51(4):278-86. doi: 10.1111/j.1423-0410.1986.tb01969.x.