Department of Anesthesiology, Shengjing Hospital of China Medical University, Shenyang, Liaoning Province, People's Republic of China.
Department of Health Management, Shengjing Hospital of China Medical University, Shenyang, Liaoning Province, People's Republic of China.
Drug Des Devel Ther. 2024 Oct 21;18:4681-4692. doi: 10.2147/DDDT.S475205. eCollection 2024.
The adverse effects and drug abuse issues associated with opioid drugs have made finding a safe and effective alternative a focus of research. Oliceridine has attracted attention for its lower adverse reactions, such as respiratory depression and gastrointestinal issues, compared to traditional opioids, and is considered a promising candidate for addressing the current limitations in opioid therapy. This article explored the knowledge structure of oliceridine through bibliometric analysis, highlighting its clinical applications in managing acute pain and its mechanisms that may reduce addiction risk. Our bibliometric analysis highlighted hotspots and trends in oliceridine research, guiding future studies on its safety and efficacy in pain management.
This study utilized the Web of Science Core Collection database to search for articles related to oliceridine from 2013 to 2024. Systematic analysis was conducted on publication, country, institution, author, journal, references, and keywords. The software Citespace, Vosviewer, and Bibliometrix were employed to visualize bibliometric analysis.
From 2013 to 2024, 159 articles on oliceridine were published in 98 journals by 158 institutions from 28 countries. The United States has rapidly developed in this field, providing significant momentum. Keyword clustering analysis revealed that research on oliceridine primarily focused on exploring its molecular and pharmacological mechanisms and conducting clinical studies to evaluate its efficacy and safety in pain management. Analyses of the strongest citation bursts with references and keywords indicated that protein-biased ligands and oliceridine were hotspots. The emergence of divergent views regarding oliceridine's biased agonism will lead to future hotspots focusing on the underlying mechanisms of biased signaling by G protein-coupled receptors and drug design.
Bibliometric analysis provides insights into the current hotspots and emerging areas of oliceridine, which can guide future research. The widespread attention and clinical application of oliceridine lay a solid foundation for further drug development and clinical trials.
阿片类药物的不良反应和药物滥用问题使得寻找一种安全有效的替代品成为研究的焦点。与传统阿片类药物相比，奥列利定因其较低的不良反应（如呼吸抑制和胃肠道问题）而引起关注，被认为是解决当前阿片类药物治疗局限性的有前途的候选药物。本文通过文献计量学分析探讨了奥列利定的知识结构，强调了其在急性疼痛管理中的临床应用及其可能降低成瘾风险的机制。我们的文献计量学分析突出了奥列利定研究的热点和趋势，指导了未来关于其在疼痛管理中安全性和有效性的研究。
本研究使用 Web of Science 核心合集数据库，从 2013 年至 2024 年检索了与奥列利定相关的文章。对出版物、国家、机构、作者、期刊、参考文献和关键词进行了系统分析。使用 Citespace、Vosviewer 和 Bibliometrix 软件对文献计量学分析进行可视化。
从 2013 年至 2024 年，来自 28 个国家的 158 个机构在 98 种期刊上发表了 159 篇关于奥列利定的文章。美国在这一领域迅速发展，提供了巨大的动力。关键词聚类分析表明，奥列利定的研究主要集中在探索其分子和药理学机制以及进行临床研究，以评估其在疼痛管理中的疗效和安全性。对参考文献和关键词的最强引文爆发分析表明，蛋白偏向配体和奥列利定是热点。对于奥列利定的偏向激动作用存在不同观点的出现，将导致未来的热点集中在 G 蛋白偶联受体的偏向信号转导的潜在机制和药物设计上。
文献计量学分析提供了奥列利定当前热点和新兴领域的见解，可以指导未来的研究。奥列利定的广泛关注和临床应用为进一步的药物开发和临床试验奠定了基础。
