The Seventh Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen, Guangdong, China.
Shenzhen Bao'an Chinese Medicine Hospital, Guangzhou University of Chinese Medicine, Shenzhen, Guangdong, China.
Front Endocrinol (Lausanne). 2024 Oct 11;15:1431223. doi: 10.3389/fendo.2024.1431223. eCollection 2024.
The oxidative balance score (OBS) is a composite indicator that evaluates the balance between pro-oxidants and antioxidants in one's diet and lifestyle. However, the relationship between OBS and circadian syndrome (CircS) has remained unexplored. This investigation aimed to determine a correlation between OBS and CircS.
This population-based study examined 7,202 participants from the 2005 to 2018 National Health and Nutrition Examination Survey (NHANES), 1,433 of whom had CircS. We utilized weighted multivariate logistic regression, trend tests, subgroup analysis, and interaction tests to evaluate the correlation between OBS (total OBS, dietary OBS, and lifestyle OBS) and CircS. Restricted cubic splines (RCS) models and threshold effect analysis were used to explore nonlinear relationships.
Multivariate logistic regression analysis indicated that the protective factor for CircS was a high OBS level (total OBS: Odds ratio (OR) = 0.95, 95% Confidence interval (CI): 0.93-0.97; dietary OBS: OR = 0.98, 95% CI: 0.96-1.00; lifestyle OBS: OR = 0.65, 95% CI: 0.61-0.69). Compared to the quartile 1 group, OBS (total OBS, dietary OBS, and lifestyle OBS) was negatively and statistically significantly associated with the risk of developing Circs in the quartile 4 group (total OBS: OR = 0.47, 95% CI: 0.32-0.70; dietary OBS: OR = 0.69, 95% CI: 0.48-0.99; lifestyle OBS: OR = 0.07, 95% CI: 0.04-0.11). According to subgroup analysis and interaction tests, there was an interaction effect between the association of lifestyle OBS and CircS in terms of education level ( for interaction = 0.01). Furthermore, we observed a nonlinear negative relationship between lifestyle OBS and CircS prevalence, with inflection points at 6 ( for nonlinearity = 0.002).
The results showed a substantial negative connection between OBS and CircS. Encouraging foods filled with antioxidants and antioxidant-rich lifestyles may reduce the risk of CircS.
氧化平衡评分（OBS）是一个综合指标，用于评估饮食和生活方式中促氧化剂和抗氧化剂之间的平衡。然而，OBS 与昼夜节律紊乱（CircS）之间的关系尚未得到探索。本研究旨在确定 OBS 与 CircS 之间的相关性。
本研究采用基于人群的方法，对 2005 年至 2018 年全国健康和营养检查调查（NHANES）中的 7202 名参与者进行了研究，其中 1433 名参与者患有 CircS。我们利用加权多变量逻辑回归、趋势检验、亚组分析和交互检验来评估 OBS（总 OBS、饮食 OBS 和生活方式 OBS）与 CircS 之间的相关性。限制性立方样条（RCS）模型和阈值效应分析用于探索非线性关系。
多变量逻辑回归分析表明，CircS 的保护因素是高 OBS 水平（总 OBS：比值比（OR）=0.95，95%置信区间（CI）：0.93-0.97；饮食 OBS：OR=0.98，95%CI：0.96-1.00；生活方式 OBS：OR=0.65，95%CI：0.61-0.69）。与第 1 四分位组相比，OBS（总 OBS、饮食 OBS 和生活方式 OBS）与第 4 四分位组 Circs 发病风险呈负相关且具有统计学意义（总 OBS：OR=0.47，95%CI：0.32-0.70；饮食 OBS：OR=0.69，95%CI：0.48-0.99；生活方式 OBS：OR=0.07，95%CI：0.04-0.11）。根据亚组分析和交互检验，生活方式 OBS 与 CircS 之间存在教育水平的交互作用（ for interaction=0.01）。此外，我们观察到生活方式 OBS 与 CircS 患病率之间存在非线性负相关关系，拐点为 6（ for nonlinearity=0.002）。
结果表明，OBS 与 CircS 之间存在显著的负相关关系。鼓励摄入富含抗氧化剂的食物和富含抗氧化剂的生活方式可能会降低 CircS 的风险。
