Department of Reproductive Medicine, Binzhou Medical University Hospital, Binzhou, China.
Department of Radiology, Binzhou Medical University Hospital, Binzhou, China.
Front Endocrinol (Lausanne). 2024 Jul 30;15:1386021. doi: 10.3389/fendo.2024.1386021. eCollection 2024.
The correlation between oxidative stress and female infertility pathogenesis was established, and the oxidative balance score (OBS) can serve as a measure of overall oxidative stress burden within an individual. Prior reports have not addressed the relationship between OBS and female infertility. This study endeavors to investigate the association between infertility risk in female and OBS.
The analysis focused on data from the National Health and Nutrition Examination Survey 2013-2018. OBS was determined from 16 dietary components and 4 lifestyle components. Multivariate logistic regression was employed to investigate the relationship between OBS and female infertility. Further stratified analysis was conducted to examine the associations across various subgroups. To elucidate the dose-response relationship between infertility risk in female and OBS, a restricted cubic spline function was employed.
The study included a total of 1410 participants. Through weighted multivariable logistic regression analysis, we observed a consistent inverse correlation between OBS and the risk of female infertility [OR (95% CI) = 0.97 (0.95, 0.99), p = 0.047]. When participants were segregated into quartiles based on OBS, those in the highest quartile had a 61% [OR (95% CI) = 0.39 (0.2, 0.79), p = 0.01] reduced risk of infertility compared to those in the lowest quartile of OBS. A trend test assessing OBS by quartile also revealed the relationship between OBS and female infertility. This correlation remained constant across both dietary and lifestyle OBS. Additionally, lifestyle OBS and female infertility exhibited a nonlinear association. A sensitivity analysis verified the consistency of our findings.
The study found that a higher OBS is associated with a lower prevalence of female infertility. These results emphasized the potential role of oxidative homeostasis in the pathogenesis of infertility and highlighted the importance of follow-up studies and prevention strategies.
氧化应激与女性不孕发病机制之间存在关联，氧化平衡评分（OBS）可以作为个体整体氧化应激负担的衡量指标。先前的报告并未涉及 OBS 与女性不孕之间的关系。本研究旨在探讨女性不孕风险与 OBS 之间的关系。
本分析重点关注了 2013-2018 年全国健康与营养调查的数据。OBS 由 16 种饮食成分和 4 种生活方式成分确定。采用多变量逻辑回归分析 OBS 与女性不孕之间的关系。进一步进行了分层分析，以检验各个亚组之间的关联。为了阐明女性不孕风险与 OBS 之间的剂量-反应关系，采用了受限立方样条函数。
本研究共纳入 1410 名参与者。通过加权多变量逻辑回归分析，我们观察到 OBS 与女性不孕风险之间呈一致的负相关[比值比（95%置信区间）=0.97（0.95，0.99），p=0.047]。当根据 OBS 将参与者分为四组时，与 OBS 最低四分位数组相比，OBS 最高四分位数组的不孕风险降低了 61%[比值比（95%置信区间）=0.39（0.2，0.79），p=0.01]。通过四分位数评估 OBS 的趋势检验也显示了 OBS 与女性不孕之间的关系。这种相关性在饮食和生活方式 OBS 中均保持不变。此外，生活方式 OBS 和女性不孕之间存在非线性关联。敏感性分析验证了我们发现的一致性。
本研究发现，较高的 OBS 与较低的女性不孕患病率相关。这些结果强调了氧化平衡在不孕发病机制中的潜在作用，并突出了进行后续研究和采取预防策略的重要性。
