Blaizot S
Ann Nutr Aliment. 1979;33(3):363-83.
Weanling male rats were fed ad libitum for 6 weeks with a normal or vitamin-A-deficient diet and then meal-fed 1 1/2 hours per 24 hours a 65 p. 100 glucose diet for not less than 3 weeks. The stomach of meal-fed rats develop and food intake is sufficient to ensure a normal rate of growth until deficients reached a plateau of weight. After the single daily meal the respiratory quotients are remaining high (QR greater than 1) all throught the day and decreases during the night (0,8) with all the animals. Fasting glycemia, insulinemia and liver glycogen of meal-feds are higher than ad libitum rats ones, but lower in deficients than in controls. Activities of NADPH2-linked enzymes (G6PDH, 6PGDH and NADP malate DH) are increased in meal-feeding, but avitaminosis A reduces by half this increase.
断乳雄性大鼠自由采食正常饮食或维生素A缺乏饮食6周，然后每24小时定时喂食1个半小时含65%葡萄糖的饮食，持续不少于3周。定时喂食的大鼠胃发育良好，食物摄入量足以确保正常生长速度，直到体重达到稳定状态。每天单次喂食后，所有动物的呼吸商全天都保持较高水平（呼吸商大于1），夜间降低（至0.8）。定时喂食大鼠的空腹血糖、胰岛素血症和肝糖原水平高于自由采食的大鼠，但维生素A缺乏组低于对照组。定时喂食时，与NADPH2相关的酶（葡萄糖-6-磷酸脱氢酶、6-磷酸葡萄糖酸脱氢酶和苹果酸脱氢酶）的活性增加，但维生素A缺乏会使这种增加减半。
