Blaizot S, Bonmort J, Garcin H, Higueret P
Ann Nutr Aliment. 1978;32(1):93-109.
We have studied the variations of the blood glucose and insulin concentrations of control and vitamin A-deficient rats after administration of glucose by various ways. The avitaminosis decreases the initial glycaemia and insulinaemia in fasting rats. It seems that the insulin release from the pancreas of the deficient rats is normal after a moderate treatment: for example after a single injection of glucose 0,5 g/kg in the carotide, or during the digestion of a mixed meal (rats trained to eat their day's food in a short time), or during an intestinal perfusion in vivo of weak concentrated glucose solutions (0,5 to 2 g/l). But after meal feeding a glucose rich diet (65 p. cent) or during intestinal perfusions of solutions with a higher glucose content (up to 15 g/l) the hyper-insulinaemia is fleeting in the deficient rats and its appeared highest hyperglycaemia in some perfused animals. The endocrine regulations of the vitamin A-deficient rats are considered in the discussion.
我们研究了通过不同方式给对照大鼠和维生素A缺乏大鼠注射葡萄糖后，它们血糖和胰岛素浓度的变化。维生素缺乏症会降低空腹大鼠的初始血糖和胰岛素血症。似乎在适度治疗后，缺乏维生素A的大鼠胰腺释放胰岛素是正常的：例如，在通过颈动脉单次注射0.5 g/kg葡萄糖后，或在混合餐消化期间（训练大鼠在短时间内吃完一天食物的情况下），或在体内肠道灌注低浓度葡萄糖溶液（0.5至2 g/l）期间。但是，在喂食富含葡萄糖的饮食（65%）后，或在肠道灌注更高葡萄糖含量的溶液（高达15 g/l）期间，缺乏维生素A的大鼠的高胰岛素血症是短暂的，并且在一些灌注动物中出现了最高的高血糖症。讨论中考虑了维生素A缺乏大鼠的内分泌调节。
