Zuo Yue, Wang Jiawei, Gong Zhexuan, Liu Fulin, Liu Tongtong
Department of Cardiovascular Surgery, Affiliated Hospital of Hebei University, Hebei, China.
Department of Anaesthesiology, Affiliated Hospital of Hebei University, Hebei, China.
Psychiatry Clin Psychopharmacol. 2024 Sep 1;34(3):265-271. doi: 10.5152/pcp.2024.23810. eCollection 2024 Sep.
This article examines the relationship between patent foramen ovale (PFO) and migraine, emphasizing the mechanisms underlying the connection and the historical status of transcatheter PFO closure as a treatment for migraine. Patent foramen ovale is the most prevalent congenital cardiac defect in adults and frequently co-occurs with migraine, particularly migraine with aura. This article reviews several studies that have identified a significant prevalence of PFO in patients with migraine, implying that PFO and migraine may be more closely associated than previously thought. The underlying mechanisms of this association involve the transfer of emboli from the venous system to systemic circulation through the PFO, which can result in a range of clinical conditions. Transcatheter PFO closure therapy has demonstrated benefits in some patients with migraine; however, additional research is required to determine its effectiveness and safety. This article offers a comprehensive review of the current understanding of the link between PFO and migraine and emphasizes the need for further research in this field.
本文探讨卵圆孔未闭（PFO）与偏头痛之间的关系，着重阐述两者关联背后的机制以及经导管封堵卵圆孔未闭作为偏头痛治疗手段的历史地位。卵圆孔未闭是成人中最常见的先天性心脏缺陷，常与偏头痛，尤其是伴有先兆的偏头痛同时出现。本文回顾了多项研究，这些研究发现偏头痛患者中卵圆孔未闭的患病率颇高，这意味着卵圆孔未闭与偏头痛的关联可能比之前认为的更为紧密。这种关联的潜在机制包括栓子通过卵圆孔未闭从静脉系统转移至体循环，这可能导致一系列临床病症。经导管封堵卵圆孔未闭治疗已在一些偏头痛患者中显示出益处；然而，还需要更多研究来确定其有效性和安全性。本文全面综述了目前对卵圆孔未闭与偏头痛之间联系的认识，并强调了该领域进一步研究的必要性。
