Bayala Yannick Laurent Tchenadoyo, Ouedraogo Issa, Mourfou Hervé Eric, Son Bakoubassé Aïssata, Yameogo Wendyam Nadège, Tinni Ismael Ayouba, Zabsonré Tiendrébéogo Wendlassida Joëlle Stéphanie, Ouedraogo Dieu-Donné
Rheumatology Department Bogodogo University Hospital Center Ouagadougou Burkina Faso.
Anatomopathology Department Bogodogo University Hospital Center Ouagadougou Burkina Faso.
Clin Case Rep. 2024 Oct 24;12(11):e9509. doi: 10.1002/ccr3.9509. eCollection 2024 Nov.
Differentiating Adult-Onset Still's Disease (AOSD) from lymphoma is challenging. A 23-year-old female presented with polyarthralgia, fever, rash, lymphadenopathy, and abnormal labs. She met AOSD criteria and was diagnosed with non-Hodgkin lymphoma. Treatment led to improvement.
The differentiation between Adult-onset Still's Disease (AOSD) and lymphoma remains challenging in our context. The Faustrel score facilitates the simultaneous diagnosis of these conditions. A 23-year-old woman presented with chronic polyarthralgia in a febrile context. A physical examination revealed peripheral joint syndrome, a maculopapular rash on the trunk, and peripheral lymphadenopathy. Laboratory tests showed neutrophils leukocytosis, hyperferritinemia, and a glycosylated ferritin fraction of 12%. A lymph node biopsy revealed a malignant non-Hodgkin lymphoma, and the patient met the diagnostic criteria for AOSD according to Faustrel. She received corticosteroid therapy and four courses of Rituximab. After 6 months, clinical and biological improvements were noted. It is essential to consider the possibility of an association between atypical clinical presentations of lymphoma and AOSD.
鉴别成人斯蒂尔病（AOSD）与淋巴瘤具有挑战性。一名23岁女性出现多关节痛、发热、皮疹、淋巴结病及实验室检查异常。她符合AOSD标准，却被诊断为非霍奇金淋巴瘤。治疗后病情改善。
在我们的环境中，区分成人斯蒂尔病（AOSD）和淋巴瘤仍然具有挑战性。福斯特雷尔评分有助于同时诊断这些疾病。一名23岁女性在发热情况下出现慢性多关节痛。体格检查发现外周关节综合征、躯干斑丘疹皮疹和外周淋巴结病。实验室检查显示中性粒细胞白细胞增多、高铁蛋白血症和糖基化铁蛋白分数为12%。淋巴结活检显示为恶性非霍奇金淋巴瘤，根据福斯特雷尔标准该患者符合AOSD诊断标准。她接受了皮质类固醇治疗和四个疗程的利妥昔单抗治疗。6个月后，临床和生物学指标出现改善。必须考虑淋巴瘤非典型临床表现与AOSD之间关联的可能性。
