Zhang Ruolan, Perekatt Ansu, Chen Lei
School of Life Science and Technology, Key Laboratory of Developmental Genes and Human Disease Southeast University Nanjing China.
Department of Chemistry and Chemical Biology Stevens Institute of Technology Hoboken New Jersey USA.
MedComm (2020). 2024 Oct 25;5(11):e776. doi: 10.1002/mco2.776. eCollection 2024 Nov.
Metabolism serves not only as the organism's energy source but also yields metabolites crucial for maintaining tissue homeostasis and overall health. Intestinal stem cells (ISCs) maintain intestinal homeostasis through continuous self-renewal and differentiation divisions. The intricate relationship between metabolic pathways and intestinal homeostasis underscores their crucial interplay. Metabolic pathways have been shown to directly regulate ISC self-renewal and influence ISC fate decisions under homeostatic conditions, but the cellular and molecular mechanisms remain incompletely understood. Understanding the intricate involvement of various pathways in maintaining intestinal homeostasis holds promise for devising innovative strategies to address intestinal diseases. Here, we provide a comprehensive review of recent advances in the regulation of intestinal homeostasis. We describe the regulation of intestinal homeostasis from multiple perspectives, including the regulation of intestinal epithelial cells, the regulation of the tissue microenvironment, and the key role of nutrient metabolism. We highlight the regulation of intestinal homeostasis and ISC by nutrient metabolism. This review provides a multifaceted perspective on how intestinal homeostasis is regulated and provides ideas for intestinal diseases and repair of intestinal damage.
新陈代谢不仅是生物体的能量来源，还产生对维持组织内稳态和整体健康至关重要的代谢产物。肠道干细胞（ISC）通过持续的自我更新和分化分裂来维持肠道内稳态。代谢途径与肠道内稳态之间的复杂关系凸显了它们之间至关重要的相互作用。研究表明，代谢途径在稳态条件下可直接调节ISC的自我更新并影响ISC的命运决定，但其细胞和分子机制仍未完全清楚。了解各种途径在维持肠道内稳态中的复杂参与，有望为制定治疗肠道疾病的创新策略提供思路。在此，我们对肠道内稳态调节的最新进展进行全面综述。我们从多个角度描述肠道内稳态的调节，包括肠道上皮细胞的调节、组织微环境的调节以及营养代谢的关键作用。我们强调营养代谢对肠道内稳态和ISC的调节作用。本综述从多方面阐述了肠道内稳态是如何被调节的，并为肠道疾病及肠道损伤修复提供了思路。
