Effects of reduced uterine blood flow on accelerations and decelerations in heart rate of fetal sheep.

Experiments were conducted in unanesthetized fetal sheep during the last third of gestation to examine the effects of prolonged reversible reductions in uterine blood flow on mean fetal heart rate, accelerations and decelerations in fetal heart rate, and fetal arterial pressure. With use of a Teflon vascular clamp placed around the maternal common internal iliac artery, uterine blood flow was reduced, leading to a reduction in fetal arterial oxygen saturation from 60% to 30% for 2 hours. This was associated with an initial transient fetal bradycardia and hypertension followed by tachycardia. Mean fetal heart rate remained significantly elevated for 2 hours following the release of the vascular clamp. There was no change in the number, amplitude, or duration of accelerations, but there was a significant increase in both the number and amplitude of decelerations during the period of reduced uterine blood flow.