沉默的预测因子：探索严重 COVID-19 中半乳糖凝集素-3 和鸢尾素的故事。
The silent predictors: exploring galectin-3 and Irisin's tale in severe COVID-19.
机构信息
Department of Pharmacology with Toxicology, University of Nis Faculty of Medicine, Bul. dr Zorana Djindjica 81 Nis, Nis, 18000, Serbia.
University Hospital Medical Center, Bezanijska kosa, Belgrade, Serbia.
出版信息
BMC Res Notes. 2024 Oct 27;17(1):324. doi: 10.1186/s13104-024-06978-3.
OBJECTIVE
This study aimed to evaluate the roles of galectin-3 and irisin as biomarkers in predicting severe outcomes in COVID-19 patients.
RESULTS
We analyzed serum levels of galectin-3 and irisin in 59 patients with severe COVID-19 and 30 healthy controls. Elevated galectin-3 levels were associated with increased risks of mortality, need for intensive care, and severe acute respiratory distress syndrome. The optimal cut-off value for galectin-3 was 13.47 ng/ml, with a sensitivity of 72.7% and specificity of 76.6%. Irisin levels did not differ significantly between survivors and non-survivors at admission or on the 3rd day post-admission, but approached significance on the 7th day. These findings suggest that galectin-3 could be a valuable prognostic biomarker for severe COVID-19 outcomes, while irisin's role remains to be clarified in further studies.
目的
本研究旨在评估半乳糖凝集素-3 和鸢尾素作为生物标志物在预测 COVID-19 患者严重结局中的作用。
结果
我们分析了 59 例重症 COVID-19 患者和 30 例健康对照者的血清半乳糖凝集素-3 和鸢尾素水平。半乳糖凝集素-3 水平升高与死亡率、需要重症监护和严重急性呼吸窘迫综合征的风险增加相关。半乳糖凝集素-3 的最佳截断值为 13.47ng/ml，灵敏度为 72.7%，特异性为 76.6%。入院时或入院后第 3 天，幸存者和非幸存者的鸢尾素水平无显著差异，但在第 7 天接近显著。这些发现表明，半乳糖凝集素-3 可能是 COVID-19 严重结局的有价值的预后生物标志物，而鸢尾素的作用仍需在进一步的研究中阐明。
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