College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, PR China.
Innovation Institute of Chinese Medicine and Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, PR China.
Medicine (Baltimore). 2024 Oct 4;103(40):e38351. doi: 10.1097/MD.0000000000038351.
This paper aims to conduct a comprehensive and insightful review and analysis of the potential targets and corresponding pathways of Chaihu Shugan Powder (CSP) for the treatment of premenstrual syndrome (PMS) using a network pharmacology approach. The review will encompass traditional applications, active ingredients of Chinese medicines, clinical applications, pharmacological mechanisms, and active ingredients.
The active ingredients, pharmacological mechanisms, and clinical applications of the herbal ingredients in the CSP formulation were summarized by searching the literature, and the main signaling pathways of the CSP formulation for the treatment of PMS were identified by network pharmacological studies.
CSP is a representative traditional Chinese medicine formula known for its liver detoxification properties and its effectiveness in alleviating depression. It is also recognized as one of the most widely used formulas for treating PMS. In this study, we systematically summarized the active ingredients and pharmacological mechanisms of the 7 traditional Chinese medicine components present in CSP. Through network pharmacology analysis, we identified 75 common targets of CSP relevant to the treatment of PMS. These targets were predominantly concentrated within 17 specific signaling pathways, elucidating the potential molecular mechanisms underlying CSP's therapeutic effects on PMS.
In this paper, we have reviewed CSP and PMS, investigated the potential targets and corresponding pathways of CSP for the treatment of PMS, and systematically summarized the active ingredients and pharmacological mechanisms of 7 herbal components. In addition, 17 pathways of CSP for PMS were identified for future research and clinical application. However, the specific mechanism of action of CSP for the treatment of PMS is only based on literature and online pharmacological studies, and no basic or clinical experiments have been conducted. In addition, CSP has many components with complex and varied interactions, and the effects of certain compounds may be overlooked. Based on the present findings, it is beneficial to further explore the mechanism of action of the new effector compounds and the prospect of their application in basic research and clinical trials. In conclusion, the revelation of new effector compounds and mechanisms of action is conducive to the further clinical application of CSP, the discovery of new targets for PMS, and the modernization of Chinese medicine.
本文采用网络药理学方法，对柴胡疏肝散治疗经前期综合征（PMS）的潜在靶点及相关通路进行全面深入的综述和分析。该综述将涵盖传统应用、中药活性成分、临床应用、药理机制和活性成分。
通过文献检索，总结柴胡疏肝散方中各药味的活性成分、药理机制及临床应用，通过网络药理学研究，确定柴胡疏肝散治疗 PMS 的主要信号通路。
柴胡疏肝散是一种具有代表性的传统中药方剂，具有解毒和抗抑郁作用，也是治疗 PMS 最常用的方剂之一。本研究系统总结了柴胡疏肝散 7 味中药的活性成分和药理机制。通过网络药理学分析，确定了 75 个与治疗 PMS 相关的柴胡疏肝散共同靶点。这些靶点主要集中在 17 个特定的信号通路中，阐明了柴胡疏肝散治疗 PMS 的潜在分子机制。
本文综述了柴胡疏肝散与 PMS，探讨了柴胡疏肝散治疗 PMS 的潜在靶点及相关通路，系统总结了 7 味中药的活性成分和药理机制，并对柴胡疏肝散治疗 PMS 的 17 条通路进行了探讨，为今后的研究和临床应用提供了参考。然而，柴胡疏肝散治疗 PMS 的具体作用机制仅基于文献和网络药理学研究，尚未进行基础或临床实验。此外，柴胡疏肝散成分复杂，相互作用多样，某些化合物的作用可能被忽视。基于目前的研究结果，进一步探索新效应化合物的作用机制及其在基础研究和临床试验中的应用前景是有益的。综上所述，新效应化合物和作用机制的揭示有利于柴胡疏肝散的进一步临床应用，有利于 PMS 新靶点的发现，也有利于中药现代化。
