Department of Neurology, Haeundae Paik Hospital, Inje University College of Medicine, Busan, Republic of Korea.
Department of Radiology, Haeundae Paik Hospital, Inje University College of Medicine, Busan, Republic of Korea.
Medicine (Baltimore). 2024 Oct 11;103(41):e40077. doi: 10.1097/MD.0000000000040077.
Increased choroid plexus (ChP) volume is well known to be associated with glymphatic system dysfunction. This study aimed to investigate glymphatic system function in patients with transient global amnesia (TGA) compared to healthy controls through ChP volumes measurements. We retrospectively enrolled patients with TGA from our hospital, as well as healthy controls. This was retrospectively observational study followed STROBE guideline. All participants underwent brain magnetic resonance imaging, including three-dimensional T1-weighted imaging. We analyzed and compared ChP volumes between patients with TGA and healthy controls and investigated the relationship between ChP volumes and clinical characteristics in patients with TGA. We enrolled 44 patients with TGA and 47 healthy controls. Among the 44 patients with TGA, 38 experienced a single TGA event, while 6 had recurrent TGA events. ChP volumes did not significantly differ between patients with TGA and healthy controls (2.140% vs 2.089%, P = .568). However, ChP volumes were higher in patients with a single TGA event compared to those with recurrent events (2.204% vs 1.740%, P < .013). We observed a significant positive correlation between ChP volumes and age in patients with TGA (R = 0.282, P = .007). ChP volumes were not associated with the duration of amnesia in patients with TGA (R = 0.187, P = .274). We find no differences in the glymphatic system function, as demonstrated by ChP volume for the first time. This study also found a significant correlation between ChP volume and age in patients with TGA, indicating that aging influences glymphatic system function.
脉络丛（ChP）体积增加与糖质系统功能障碍密切相关。本研究旨在通过测量 ChP 体积，比较短暂性全面遗忘症（TGA）患者与健康对照组的糖质系统功能。我们回顾性地招募了我院的 TGA 患者和健康对照者。这是一项遵循 STROBE 指南的回顾性观察性研究。所有参与者均接受了脑部磁共振成像检查，包括三维 T1 加权成像。我们分析和比较了 TGA 患者和健康对照组之间的 ChP 体积，并研究了 TGA 患者 ChP 体积与临床特征之间的关系。我们共纳入 44 例 TGA 患者和 47 例健康对照者。在 44 例 TGA 患者中，38 例为单发 TGA 事件，6 例为复发性 TGA 事件。TGA 患者和健康对照组之间的 ChP 体积无显著差异（2.140% vs 2.089%，P=0.568）。然而，单发 TGA 事件患者的 ChP 体积高于复发性事件患者（2.204% vs 1.740%，P<0.013）。我们观察到 TGA 患者的 ChP 体积与年龄之间存在显著正相关（R=0.282，P=0.007）。ChP 体积与 TGA 患者的遗忘期持续时间无关（R=0.187，P=0.274）。我们首次发现 TGA 患者的糖质系统功能没有差异，表现为 ChP 体积没有差异。本研究还发现 TGA 患者的 ChP 体积与年龄之间存在显著相关性，表明年龄会影响糖质系统功能。
