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肺腺癌胃和小肠转移:1 例报告。

Gastric and small bowel metastases from lung adenocarcinoma: A case report.

机构信息

Department of Medical Oncology, Affiliated Dongyang Hospital of Wenzhou Medical University, Dongyang, Zhejiang, China.

Interventional Radiology Department, Affiliated Dongyang Hospital of Wenzhou Medical University, Dongyang, Zhejiang, China.

出版信息

Medicine (Baltimore). 2024 Oct 11;103(41):e40058. doi: 10.1097/MD.0000000000040058.

DOI:10.1097/MD.0000000000040058
PMID:39465837
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11479503/
Abstract

RATIONALE

Metastatic tumors in the stomach and small bowel are rare. This article reports a case of lung adenocarcinoma metastasizing to the stomach and small bowel.

PATIENT CONCERNS

This case study presents the medical history of a 41-year-old male construction worker with a 1-month-long cough and slight chest discomfort. Imaging revealed a tumor in the right middle lobe of the lung, with metastasis to lymph nodes in the mediastinum and right hilar region, as well as a mass in the stomach's greater curvature and multiple lymph node metastases in the abdomen. Thirty-five days after the initial consultation, the patient exhibited worsening symptoms of vomiting and melena. A follow-up computed tomography scan revealed small bowel metastasis, leading to secondary intestinal obstruction and intussusception.

DIAGNOSES

Biopsies confirmed poorly differentiated adenocarcinoma in the lung and stomach, with immunohistochemistry supporting a diagnosis of lung adenocarcinoma. Genetic testing showed no mutations or amplification in various genes.

INTERVENTIONS

The patient received interventional hemostatic treatment; however, the efficacy of the intervention was poor.

OUTCOMES

The patient experienced worsening gastrointestinal symptoms. Despite attempted intervention, the patient ultimately died 78 days after seeking medical attention.

LESSONS

The case of lung cancer metastasizing to the stomach and small bowel presented in this article demonstrates high invasiveness and rapid progression. Combined with literature reports, this type of metastasis often indicates a poor prognosis for patients. The long-term benefits of surgical resection remain unclear, and further analysis will be needed with more cases and data in the future.

摘要

背景

胃和小肠转移瘤较为罕见。本文报告了一例肺腺癌转移至胃和小肠的病例。

病例介绍

本病例研究介绍了一名 41 岁男性建筑工人的病史,他有 1 个月的咳嗽和轻微胸痛。影像学检查显示右肺中叶有肿瘤,纵隔和右肺门淋巴结转移,胃大弯有肿块,腹部有多个淋巴结转移。初次就诊 35 天后,患者出现呕吐和黑便症状加重。随访 CT 扫描显示小肠转移,导致继发性肠梗阻和肠套叠。

诊断

活检证实肺和胃的低分化腺癌,免疫组化支持肺腺癌的诊断。基因检测显示各种基因无突变或扩增。

干预措施

患者接受了介入止血治疗,但疗效不佳。

结果

患者胃肠道症状恶化。尽管进行了干预,但患者最终在就诊后 78 天死亡。

教训

本文报告的肺癌转移至胃和小肠的病例具有高度侵袭性和快速进展性。结合文献报道,这种转移通常预示着患者预后不良。手术切除的长期获益尚不清楚,未来需要更多的病例和数据进行进一步分析。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/424b/11479503/4f6c7da11652/medi-103-e40058-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/424b/11479503/8b8b8a2028e3/medi-103-e40058-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/424b/11479503/458223b3df98/medi-103-e40058-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/424b/11479503/4f6c7da11652/medi-103-e40058-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/424b/11479503/8b8b8a2028e3/medi-103-e40058-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/424b/11479503/458223b3df98/medi-103-e40058-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/424b/11479503/4f6c7da11652/medi-103-e40058-g003.jpg

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本文引用的文献

1
Gastric Metastasis of Primary Lung Cancer: Case Report and Systematic Review With Pooled Analysis.原发性肺癌胃转移:病例报告及汇总分析的系统评价
Front Oncol. 2022 Jul 8;12:922016. doi: 10.3389/fonc.2022.922016. eCollection 2022.
2
Gastric metastasis and transformation of primary lung adenocarcinoma to small cell cancer after acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors: A case report.胃转移和表皮生长因子受体酪氨酸激酶抑制剂获得性耐药后原发性肺腺癌转化为小细胞癌:一例报告。
Medicine (Baltimore). 2021 Oct 1;100(39):e27289. doi: 10.1097/MD.0000000000027289.
3
Clinical Characteristics and Prognosis of Gastrointestinal Metastases in Solid Tumor Patients: A Retrospective Study and Review of Literatures.
实体瘤患者胃肠道转移的临床特征和预后:一项回顾性研究和文献复习。
Anal Cell Pathol (Amst). 2019 Dec 20;2019:4508756. doi: 10.1155/2019/4508756. eCollection 2019.
4
Primary lung squamous cell carcinoma with gastric metastasis: A case report.原发性肺鳞癌胃转移:一例报告。
Thorac Cancer. 2019 Feb;10(2):373-377. doi: 10.1111/1759-7714.12940. Epub 2018 Dec 18.
5
A rare case of advanced lung cancer presenting as a symptomatic gastric tumor.一例罕见的以有症状的胃肿瘤形式出现的晚期肺癌病例。
Mol Clin Oncol. 2018 Apr;8(4):595-599. doi: 10.3892/mco.2018.1565. Epub 2018 Feb 2.
6
Analysis of gastrointestinal metastasis of primary lung cancer: Clinical characteristics and prognosis.原发性肺癌胃肠道转移的分析:临床特征与预后
Oncol Lett. 2017 Aug;14(2):2399-2404. doi: 10.3892/ol.2017.6382. Epub 2017 Jun 14.
7
Clinical and Endoscopic Features of Metastatic Tumors in the Stomach.胃转移性肿瘤的临床及内镜特征
Gut Liver. 2015 Sep 23;9(5):615-22. doi: 10.5009/gnl14032.
8
Role of surgical intervention in managing gastrointestinal metastases from lung cancer.肺癌胃肠道转移的外科治疗作用。
World J Gastroenterol. 2011 Oct 14;17(38):4314-20. doi: 10.3748/wjg.v17.i38.4314.
9
Surgical treatment for gastrointestinal metastasis of non-small-cell lung cancer after pulmonary resection.肺切除术后非小细胞肺癌胃肠道转移的外科治疗
Gen Thorac Cardiovasc Surg. 2011 Nov;59(11):748-52. doi: 10.1007/s11748-011-0811-3. Epub 2011 Nov 15.
10
Gastrointestinal metastasis from primary lung cancer: CT findings and clinicopathologic features.原发性肺癌的胃肠道转移:CT表现及临床病理特征
AJR Am J Roentgenol. 2009 Sep;193(3):W197-201. doi: 10.2214/AJR.08.1907.