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特应性皮炎中免疫细胞和血浆代谢物的因果关系和中介效应：一项孟德尔随机化研究。

Causal relationship and mediation effects of immune cells and plasma metabolites in atopic dermatitis: A Mendelian randomization study.

机构信息

School of Basic Medicine, Southwest Medical University, Luzhou, Sichuan, China.

出版信息

Medicine (Baltimore). 2024 Oct 11;103(41):e39932. doi: 10.1097/MD.0000000000039932.

DOI:10.1097/MD.0000000000039932
PMID:39465865
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11479512/
Abstract

Atopic dermatitis (AD) is a chronic inflammatory skin condition with complex etiology involving genetic, environmental, and immunological factors. This study employs Mendelian randomization to explore the causal relationships between immune cell phenotypes and AD, and the mediating effects of plasma metabolites. Using data from European cohorts, we identified 7 immune cell phenotypes significantly associated with AD. Mediation analysis revealed that the alpha-ketobutyrate to 4-methyl-2-oxopentanoate ratio negatively regulates CCR2 on monocytes, while the glycerol to carnitine ratio positively regulates HLA-DR on CD14- CD16- cells. These findings underscore the critical role of metabolic pathways in modulating immune responses and suggest potential dietary and therapeutic interventions for AD management. Further research should consider more diverse populations to validate these findings.

摘要

特应性皮炎（AD）是一种慢性炎症性皮肤疾病，其病因复杂，涉及遗传、环境和免疫因素。本研究采用孟德尔随机化方法来探讨免疫细胞表型与 AD 之间的因果关系，以及血浆代谢物的中介作用。我们利用来自欧洲队列的数据，确定了 7 种与 AD 显著相关的免疫细胞表型。中介分析显示，α-酮丁酸与 4-甲基-2-氧戊酸的比值负向调节单核细胞上的 CCR2，而甘油与肉碱的比值正向调节 CD14-CD16-细胞上的 HLA-DR。这些发现强调了代谢途径在调节免疫反应中的关键作用，并为 AD 的管理提供了潜在的饮食和治疗干预措施。进一步的研究应考虑更多样化的人群来验证这些发现。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2676/11479512/503193a5aa59/medi-103-e39932-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2676/11479512/861fcfe8be09/medi-103-e39932-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2676/11479512/63b60ba74cdb/medi-103-e39932-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2676/11479512/503193a5aa59/medi-103-e39932-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2676/11479512/861fcfe8be09/medi-103-e39932-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2676/11479512/97d023493312/medi-103-e39932-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2676/11479512/4067f0e9cf8e/medi-103-e39932-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2676/11479512/63b60ba74cdb/medi-103-e39932-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2676/11479512/503193a5aa59/medi-103-e39932-g005.jpg

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本文引用的文献

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A Multidisciplinary Approach Is Beneficial in Atopic Dermatitis.多学科方法对特应性皮炎有益。
Dermatol Ther (Heidelb). 2024 Jun;14(6):1443-1455. doi: 10.1007/s13555-024-01185-1. Epub 2024 May 30.
2
Role of Ubiquitin-conjugating enzyme E2 (UBE2) in two immune-mediated inflammatory skin diseases: a mendelian randomization analysis.泛素连接酶 E2（UBE2）在两种免疫介导的炎症性皮肤病中的作用：一项孟德尔随机化分析。
Arch Dermatol Res. 2024 May 25;316(6):249. doi: 10.1007/s00403-024-02976-4.
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Heterotrophic and autotrophic production of L-isoleucine and L-valine by engineered Cupriavidus necator H16.
工程化恶臭假单胞菌 H16 异养和自养生产 L-异亮氨酸和 L-缬氨酸。
Bioresour Technol. 2024 Apr;398:130538. doi: 10.1016/j.biortech.2024.130538. Epub 2024 Mar 5.
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GB12-09, a bispecific antibody targeting IL4Rα and IL31Rα for atopic dermatitis therapy.GB12 - 09，一种靶向白细胞介素4受体α（IL4Rα）和白细胞介素31受体α（IL31Rα）用于特应性皮炎治疗的双特异性抗体。
Antib Ther. 2024 Jan 5;7(1):77-87. doi: 10.1093/abt/tbad032. eCollection 2024 Jan.
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IL-31-dependent neurogenic inflammation restrains cutaneous type 2 immune response in allergic dermatitis.IL-31 依赖性神经源性炎症抑制变应性性皮炎中的皮肤 2 型免疫反应。
Sci Immunol. 2023 Oct 20;8(88):eabi6887. doi: 10.1126/sciimmunol.abi6887. Epub 2023 Oct 13.
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Role of Innate Immunity in Allergic Contact Dermatitis: An Update.固有免疫在变应性接触性皮炎中的作用：更新。
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Gut microbiota and atopic dermatitis: a two-sample Mendelian randomization study.肠道微生物群与特应性皮炎：一项两样本孟德尔随机化研究。
Front Med (Lausanne). 2023 Jun 22;10:1174331. doi: 10.3389/fmed.2023.1174331. eCollection 2023.
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Amino acid metabolism in immune cells: essential regulators of the effector functions, and promising opportunities to enhance cancer immunotherapy.免疫细胞中的氨基酸代谢：效应功能的必需调节剂，以及增强癌症免疫治疗的有希望的机会。
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The evolving landscape of biologic therapies for atopic dermatitis: Present and future perspective.特应性皮炎生物治疗的发展现状：现状与未来展望。
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