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基于经皮椎间孔腰椎椎间融合术(PE-PLIF)融合的钛与聚醚醚酮组合椎间融合器的结构设计与生物力学分析

Structural design and biomechanical analysis of a combined titanium and polyetheretherketone cage based on PE-PLIF fusion.

作者信息

Ma Lei, Xie Yutang, Zhang Kai, Chen Jing, Wang Yanqin, He Liming, Feng Haoyu, Chen Weiyi, Zhang Meng, Xue Yanru, Wu Xiaogang, Li Qiang

机构信息

Taiyuan University of Technology School of Biomedical Engineering, Taiyuan, China.

Huajin Orthopaedic Hospital, Taiyuan, 030024, China.

出版信息

Med Biol Eng Comput. 2025 Mar;63(3):707-720. doi: 10.1007/s11517-024-03214-9. Epub 2024 Oct 28.

Abstract

In lumbar spinal fusion, the titanium cage tends to cause stress shielding due to their high elastic modulus, which can lead to degenerative lesions in adjacent spinal segments. Furthermore, polyetheretherketone (PEEK) cages have certain material characteristics that do not promote bone ingrowth and fusion stability. In this study, a new cage was designed, and its biomechanical performance in percutaneous endoscopic posterior lumbar interbody fusion (PE-PLIF) was analyzed using the finite element (FE) method. A complete model of the L4-L5 lumbar spine was established, and static and harmonic vibration FE analysis models were developed based on it. The biomechanical properties of titanium, PEEK, and combined cage in PE-PLIF fusion were compared. The strain capacity of the combined fusion increased by 9.5% when compared to the titanium fusion. The surgical model under the combined fusion reduces the L5 endplate stress by 12% in the forward flexion condition and the fusion stress by 17% in the vibration condition compared to the model supported by the titanium fusion, and the differences in screw stress and mobility among the three models are not significant in multiple conditions. Consequently, the combined cage demonstrates a certain reduction in the stress-shielding effect when compared to the titanium cage; it has better fusion effect and provides theoretical support and guidance for the design of the clinical fusion cage.

摘要

在腰椎融合术中,钛合金椎间融合器因其高弹性模量往往会导致应力遮挡,这可能会导致相邻脊柱节段发生退变病变。此外,聚醚醚酮(PEEK)椎间融合器具有某些不利于骨长入和融合稳定性的材料特性。在本研究中,设计了一种新型椎间融合器,并采用有限元(FE)方法分析了其在经皮内镜下腰椎后路椎间融合术(PE-PLIF)中的生物力学性能。建立了L4-L5腰椎的完整模型,并在此基础上开发了静态和谐波振动有限元分析模型。比较了钛合金、PEEK和组合式椎间融合器在PE-PLIF融合中的生物力学性能。与钛合金融合相比,组合式融合的应变能力提高了9.5%。与钛合金融合支撑的模型相比,组合式融合下的手术模型在向前屈曲状态下可使L5终板应力降低12%,在振动状态下可使融合应力降低17%,并且三种模型在多种状态下的螺钉应力和活动度差异不显著。因此,与钛合金椎间融合器相比,组合式椎间融合器的应力遮挡效应有一定降低;它具有更好的融合效果,为临床融合椎间融合器的设计提供了理论支持和指导。

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