Ye Diya, Yuan Tianming, Jiang Mizu
Department of Gastroenterology and Pediatric Endoscopy Center, National Clinical Research Center for Child Health, National Children's Regional Medical Center, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Department of Neonatology, National Clinical Research Center for Child Health, National Children's Regional Medical Center, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Pediatr Pulmonol. 2025 Jan;60(1):e27352. doi: 10.1002/ppul.27352. Epub 2024 Oct 28.
A 2-month-old male infant presented with a persistent mild cough and a pink papule beneath the left eyelid. Imaging studies revealed diffuse lung opacities and a cystic shadow in the right middle lobe, with no evidence of bacterial or fungal infection. Skin biopsy demonstrated positive immunohistochemical staining for CD207/Langerin and CD1a, leading to a diagnosis of Langerhans-cell histiocytosis (LCH). The infant's pulmonary bullae resolved following chemotherapy, and the patient is under surveillance for recurrence. LCH, recognized for its inflammatory and malignant characteristics, often presents with multisystemic involvement, including pulmonary manifestations. Timely diagnosis and treatment are crucial for managing this rare disorder in infants.
