登革热病毒和 Zika 病毒感染：物种特异性和广泛的细胞嗜性。

DENV and ZIKV infection: Species specificity and broad cell tropism.

机构信息

Institute of Veterinary Medicine and Immunology, Sichuan Agricultural University, Chengdu, Sichuan 611130, China; Research Center of Avian Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, 611130, China; Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu, Sichuan, 611130, China; Key Laboratory of Agricultural Bioinformatics of Ministry of Education, Sichuan Agricultural University, Chengdu, Sichuan, 611130, China.

出版信息

Virology. 2024 Dec;600:110276. doi: 10.1016/j.virol.2024.110276. Epub 2024 Oct 23.

DOI:10.1016/j.virol.2024.110276

PMID:39467358

Abstract

Nearly one-third of countries worldwide have reported cases of Dengue virus (DENV) and Zika virus (ZIKV) infections, highlighting the significant threat these viruses pose to global public health. As members of the Flavivirus genus within the Flaviviridae family, DENV and ZIKV have demonstrated the ability to infect a wide range of cell lines from multiple species in vitro. However, the range of susceptible animal models is notably limited, and field studies indicate that their capacity to infect host organisms is highly restricted, with a very narrow range of target cells in vivo. The virus's ability to hijack host cellular machinery plays a crucial role in determining its cellular and species specificity. In this review, we examine how DENV and ZIKV exploit host cells to facilitate their replication, offering new insights that could inform the development of antiviral drugs and therapeutic targets.

摘要

全球近三分之一的国家报告了登革热病毒（DENV）和 Zika 病毒（ZIKV）感染病例，这凸显了这些病毒对全球公共卫生的重大威胁。DENV 和 ZIKV 属于黄病毒科黄病毒属，已证明它们能够在体外感染来自多个物种的多种细胞系。然而，易感动物模型的范围明显有限，并且现场研究表明，它们感染宿主生物体的能力受到高度限制，体内靶细胞的范围非常狭窄。病毒劫持宿主细胞机制的能力在决定其细胞和物种特异性方面起着至关重要的作用。在这篇综述中，我们研究了 DENV 和 ZIKV 如何利用宿主细胞来促进其复制，为开发抗病毒药物和治疗靶点提供了新的见解。