Bidgood Emma, Huang Joanna, Murphy Elise, Prentice Ralley, Hede Beth, Russell David
Department of Allied Health (Clinical Nutrition), The Royal Melbourne Hospital, Melbourne, Victoria, Australia.
Department of Gastroenterology, The Royal Melbourne Hospital, Melbourne, Victoria, Australia.
Nutr Clin Pract. 2025 Aug;40(4):942-949. doi: 10.1002/ncp.11237. Epub 2024 Oct 28.
Peripheral parenteral nutrition (PPN) provides an alternative nutrition support strategy to centrally administered PN for specific patients requiring short-term PN. Previous studies have demonstrated limited use of PPN and variable complication rates. This study aimed to evaluate PPN complications and usage at this center.
This was a single-center retrospective observational study of all adult patients who received at least 1 day of PPN from June 2018 to December 2023. Demographic and clinical data were collected, including complications, indications for PN and reason for PPN, duration of therapy, reason for cessation of PPN, nutrition status, energy and protein provision, and central line insertion rates.
381 patients were included, the median age was 62 (interquartile range = 28-74) years, and 235 were men (61.7%). The most common indication for PN was ileus (n = 153, 40%) followed by gastrointestinal obstruction (n = 93, 24%). The median time receiving PPN was 3 (2-4) days. Patients received a median of 65% (55%-75%) of energy and 58% (50%-69%) of protein requirements with PPN. Malnutrition was diagnosed in 47.5% (n = 181) of this cohort. Total complication rates were 8.7% (n = 33), with cannula infiltration being the most common complication (6.6%, n = 25). 213 (56%) patients proceeded to central line insertion.
PPN proved to be a safe and effective therapy for short-term PN when managed by a nutrition support team. PPN has the potential to attenuate short-term nutrition deficits and prevent central venous access device insertion in selected patients, making it a valuable nutrition support therapy.
外周肠外营养（PPN）为特定需要短期肠外营养的患者提供了一种替代中心静脉营养的营养支持策略。以往研究表明PPN的使用有限且并发症发生率各异。本研究旨在评估本中心PPN的并发症及使用情况。
这是一项单中心回顾性观察研究，纳入了2018年6月至2023年12月期间接受至少1天PPN的所有成年患者。收集了人口统计学和临床数据，包括并发症、肠外营养的适应证和PPN的原因、治疗持续时间、PPN停止的原因、营养状况、能量和蛋白质供应以及中心静脉置管率。
共纳入381例患者，中位年龄为62岁（四分位间距=28-74岁），男性235例（61.7%）。肠外营养最常见的适应证是肠梗阻（n=153，40%），其次是胃肠道梗阻（n=93，24%）。接受PPN的中位时间为3（2-4）天。患者通过PPN获得的能量中位数为需求的65%（55%-75%），蛋白质为需求的58%（50%-69%）。该队列中47.5%（n=181）的患者被诊断为营养不良。总并发症发生率为8.7%（n=33），其中套管渗漏是最常见的并发症（6.6%，n=25）。213例（56%）患者进行了中心静脉置管。
由营养支持团队管理时，PPN被证明是一种安全有效的短期肠外营养治疗方法。PPN有可能减轻短期营养缺乏，并避免在部分患者中进行中心静脉通路装置置管，使其成为一种有价值的营养支持治疗方法。
