Division of Oral Surgery and Orthodontics, Department of Dental Medicine and Oral Health, Medical University of Graz, Graz, Austria.
Department of Otorhinolaryngology, Medical University of Graz, Graz, Austria.
Clin Oral Investig. 2024 Oct 29;28(11):615. doi: 10.1007/s00784-024-06002-9.
To date, studies have only investigated the use of platelet-rich fibrin (PRF) after removal of third molars from the mandible or maxilla. Removal of the upper and lower third molars is typically combined into one session per side; therefore, this study aimed to investigate influence on PRF.
This prospective, single-blinded, randomized controlled, clinical trial (split-mouth design) included 25 patients. After third molar removal, the test group's sockets were treated with solid PRF clots, whereas the control group's sockets were conventionally treated. The primary outcome was swelling, which was measured digitally and analogously. Secondary outcomes included trismus, pus, hematoma, and clinical attachment loss (CAL) of the second molars on days 1, 3, 7, and 14. Patient-centered outcome measures and the consumption of painkillers and antibiotics were recorded on days 0-7. The t-test for paired samples, Wilcoxon test, and Chi-Square test were used for statistical analyses.
Swelling was significantly lower on day 14 in the test group (p < 0.05). No statistically significant differences were observed in pain, trismus, and CAL. In the test group, the number of painkillers taken and the number of days of intake were significantly lower (p < 0.05).
PRF caused a reduction of painkiller consumption and in the days painkillers were needed. PRF significantly considerably reduced swelling after 14 days. Owing to the lack of differences in other parameters, the integration of PRF application into routine wisdom tooth removal is critical.
PRF affects the long-term outcomes of third molar removal by reducing swelling and reducing as well as shortening painkiller consumption.
clinicaltrials.gov (NCT05089812).
迄今为止，研究仅调查了在下颌骨或上颌骨去除第三磨牙后使用富含血小板的纤维蛋白（PRF）。上下颌第三磨牙的去除通常合并在每侧一次；因此，本研究旨在调查其对 PRF 的影响。
这是一项前瞻性、单盲、随机对照、临床研究（分割口腔设计），共纳入 25 名患者。在第三磨牙去除后，实验组的窝洞用固体 PRF 凝块处理，而对照组的窝洞则进行常规处理。主要结局是肿胀，通过数字和模拟进行测量。次要结局包括第 1、3、7 和 14 天时的磨牙的牙关紧闭、脓液、血肿和临床附着丧失（CAL）。在第 0-7 天记录患者为中心的结局指标和止痛药和抗生素的消耗情况。采用配对样本 t 检验、Wilcoxon 检验和卡方检验进行统计学分析。
实验组在第 14 天的肿胀明显更低（p<0.05）。疼痛、牙关紧闭和 CAL 没有统计学上的显著差异。在实验组中，止痛药的使用量和服用天数明显更少（p<0.05）。
PRF 可减少止痛药的消耗和服用天数。PRF 可显著减少 14 天后的肿胀。由于其他参数没有差异，因此将 PRF 应用整合到常规智齿去除中至关重要。
PRF 通过减少肿胀和减少及缩短止痛药的使用来影响第三磨牙去除的长期结果。
clinicaltrials.gov（NCT05089812）。
