Pattnayak Anwesha, Ramanna Pavithra K, Mahabala Karuna Y, Edathotty Terry T, Kumaraswamy Ambikathanaya U, Duseja Shilpa
Department of Oral and Maxillofacial Surgery, Kalinga Institute of Dental Sciences, KIIT Deemed to be University, Bhubaneswar, Odisha, India, Phone: +91 7077027413, e-mail:
Department of Prosthodontics and Crown and Bridge, The Oxford Dental College, Bengaluru, Karnataka, India.
J Contemp Dent Pract. 2024 Sep 1;25(9):904-910. doi: 10.5005/jp-journals-10024-3727.
This study aims to evaluate the impact of platelet-rich fibrin (PRF) and platelet-rich plasma (PRP) on pain, swelling, trismus, soft tissue healing and bone regeneration following mandibular third molar extraction.
A systematic review was conducted from a period of January 2014 to June 2024 using PRISMA guidelines. The search strategy included databases such as Scopus, PubMed, Google Scholar, and Cochrane Central Register of Controlled Trials, using key terms related to "PRF", "PRP", oral surgery, and third molars. PICO criteria followed were - Patient and population (P): Patient with mandibular third molar impacted tooth. Intervention (I): PRF; Comparator or control group (C): PRP; Outcomes (O): Impact on pain, swelling, trismus, soft tissue healing and bone regeneration following mandibular third molar extraction. National Heart, Lung, and Blood Institute (NHLBI) quality assessment tool was also employed. Data was extracted and analyzed.
Six articles met the inclusion criteria. Both materials showed potential in promoting bone and soft tissue regeneration. Out of which 1 was a split-mouth prospective clinical study, 3 were split-mouth comparative study, 2 were unilateral randomized comparative prospective study. While four studies showed a significant improvement in the soft tissue wound healing and increase in bone density in PRF site comparatively, two studies showed no significant difference between PRF and PRP with regard to pain, trismus, swelling and bone formation in the third molar extraction socket region after the placement. Based on NHLBI quality assessment tool, all the studies scored predominantly one, and hence were found good.
Both "PRF" and "PRP" positively influence healing after mandibular third molar extraction. Platelet-rich fibrin offers an advantage due to its ease of preparation and complete autologous nature.
The impacted third molars created a variety of problems and required their extraction. Because mandibular third molars have denser cortical bone, they are more likely to experience postoperative complications. Successful surgical extraction typically occurs between ages 24 and 30, but outcomes vary based on several factors, including operator experience and patient characteristics. Recent advancements emphasize the role of oxygen and growth factors in wound healing, particularly "PRP" and "PRF". How to cite this article: Pattnayak A, Ramanna PK, Mahabala KY, Impact of Platelet-rich Plasma and Platelet-rich Fibrin in Mandibular Third Molar Extraction: A Systematic Review. J Contemp Dent Pract 2024;25(9):904-910.
本研究旨在评估富血小板纤维蛋白（PRF）和富血小板血浆（PRP）对下颌第三磨牙拔除术后疼痛、肿胀、张口受限、软组织愈合及骨再生的影响。
采用PRISMA指南，对2014年1月至2024年6月期间的研究进行系统评价。检索策略包括Scopus、PubMed、谷歌学术和Cochrane对照试验中央注册库等数据库，使用与“PRF”“PRP”、口腔外科及第三磨牙相关的关键词。遵循的PICO标准为：患者和人群（P）：下颌第三磨牙阻生患者；干预措施（I）：PRF；对照或对照组（C）：PRP；结局指标（O）：对下颌第三磨牙拔除术后疼痛、肿胀、张口受限、软组织愈合及骨再生的影响。同时使用了美国国立心肺血液研究所（NHLBI）质量评估工具。对数据进行提取和分析。
6篇文章符合纳入标准。两种材料在促进骨和软组织再生方面均显示出潜力。其中1篇为口内对照前瞻性临床研究，3篇为口内对照比较研究，2篇为单侧随机对照前瞻性研究。4项研究显示，PRF部位的软组织伤口愈合有显著改善，骨密度增加；2项研究表明，在第三磨牙拔牙窝区域植入PRF和PRP后，在疼痛、张口受限、肿胀和骨形成方面无显著差异。根据NHLBI质量评估工具，所有研究得分大多为1分，因此质量良好。
“PRF”和“PRP”均对下颌第三磨牙拔除术后的愈合有积极影响。富血小板纤维蛋白因其制备简便且完全自体的特性而具有优势。
阻生第三磨牙会引发多种问题，需要拔除。由于下颌第三磨牙的皮质骨较致密，术后更易出现并发症。成功的手术拔除通常发生在24至30岁之间，但结局因多种因素而异，包括术者经验和患者特征。最近的进展强调了氧气和生长因子在伤口愈合中的作用，尤其是“PRP”和“PRF”。如何引用本文：Pattnayak A, Ramanna PK, Mahabala KY, 富血小板血浆和富血小板纤维蛋白在下颌第三磨牙拔除术中的影响：一项系统评价。《当代牙科实践杂志》2024；25（9）：904 - 910。
