帕金森病患者血清α-klotho水平

Serum alpha klotho levels in Parkinson's Disease.

作者信息

Yalcin Ahmet, Gemci Emine, Yurumez Busra, Yilmaz Rezzak, Varli Murat, Atmis Volkan, Akbostancı M Cenk, Yazihan Nuray

机构信息

Geriatric Medicine Department, Ankara University School of Medicine, Ankara Üniversitesi Tıp Fakültesi Dekanlığı Morfoloji Yerleşkesi, A. Adnan Saygun Cad. No: 35, Altındağ/Ankara, Turkey.

Neurology Department, Ankara University School of Medicine, Ankara, Turkey.

出版信息

Neurol Sci. 2025 Feb;46(2):743-749. doi: 10.1007/s10072-024-07809-w. Epub 2024 Oct 29.

DOI:10.1007/s10072-024-07809-w

PMID:39467935

Abstract

PURPOSE

Parkinson's Disease (PD), a neurodegenerative disorder, is associated with substantial morbidity. α-Klotho, an anti-aging protein known for its neuroprotective properties, has gained attention. This study aims to assess serum levels of α-Klotho in PD patients.

METHODS

This study is a cross-sectional case-control study. PD was diagnosed according to UK Parkinson Disease Society Brain Bank criteria. Serum α-Klotho level was measured using a commercially available enzyme-linked immunosorbent assay.

RESULTS

Of the 314 participants in the study, 157 were patients with PD and 157 were controls. Lower levels of α-Klotho were observed in PD (0.85 nmol/L) in comparison to the controls (1.47 nmol/L, p < 0.001). α-Klotho levels were also significantly lower among PD patients with dementia compared to PD patients without dementia. In logistic regression analysis, α-Klotho (OR: 0.04, p < 0.001) demonstrated a significant relationship between PD. A significant correlation was identified between α-Klotho levels and Mini-Mental State Examination scores in PD patients. The sensitivity and the specifity of α-Klotho were 90% and 65% for predicting PD.

CONCLUSIONS

Our findings suggest that α-klotho could potentially serve as a biomarker. However additional studies are needed to confirm our findings.

摘要

目的

帕金森病（PD）是一种神经退行性疾病，与严重的发病率相关。α-klotho是一种以其神经保护特性而闻名的抗衰老蛋白，已受到关注。本研究旨在评估PD患者血清中α-klotho的水平。

方法

本研究为横断面病例对照研究。根据英国帕金森病协会脑库标准诊断PD。使用市售的酶联免疫吸附测定法测量血清α-klotho水平。

结果

在该研究的314名参与者中，157名是PD患者，157名是对照组。与对照组（1.47 nmol/L，p < 0.001）相比，PD患者中观察到较低水平的α-klotho（0.85 nmol/L）。与无痴呆的PD患者相比，痴呆的PD患者中α-klotho水平也显著较低。在逻辑回归分析中，α-klotho（OR：0.04，p < 0.001）显示与PD之间存在显著关系。在PD患者中，α-klotho水平与简易精神状态检查得分之间存在显著相关性。α-klotho预测PD的敏感性和特异性分别为90%和65%。