Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.
Department of Urology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.
J Nutr Health Aging. 2024 Jun;28(6):100224. doi: 10.1016/j.jnha.2024.100224. Epub 2024 Apr 5.
OBJECTIVES: Maintaining ideal cardiovascular health (CVH) is believed to have potential anti-aging benefits. The American Heart Association (AHA) recently updated the "Life's Essential 8 (LE8)" metrics to measure ideal CVH, but its connection with the anti-aging protein klotho is still unclear. We aimed to explore the relationship between ideal cardiovascular health and serum anti-aging protein klotho in a nationally representative US middle-aged and older population. DESIGN: A cross-sectional study. SETTING: The National Health and Nutrition Examination Survey (2007-2016). PARTICIPANTS: A total of 9457 middle-aged and older participants. MEASUREMENTS: Ideal CVH scores and their components were defined according to the guidelines set by the AHA. Serum klotho detected by enzyme-linked immunosorbent assay. Weighted multivariable linear regression and restricted cubic spline were employed to examine the association between CVH score and klotho. Subgroup analyses were conducted, stratified by age (40-59 and 60-79), sex (Male and Female), race (Mexican American, non-Hispanic White, non-Hispanic Black, and Others) and chronic kidney disease (Yes and No) in fully adjusted models. RESULTS: A total of 9457 middle-aged and older participants were included in this study, with a mean age of 55.27 ± 0.17 years. The mean serum klotho level in the population was 849.33 ± 5.39 pg/mL. After controlling for potential confounders, the LE8 score showed a positive correlation with serum klotho levels (β: 1.32; 95% CI 0.73, 1.91), and a non-linear dose-response relationship was observed. Furthermore, we also discovered a positive relationship between health behaviors score and health factors score and serum klotho levels (β: 0.48; 95% CI 0.07, 0.88 and β: 1.05; 95% CI 0.54, 1.56, respectively), particularly a stronger correlation between health factors and serum klotho. In the subgroup analysis, we observed a significant interaction between LE8 score and sex and race. (P for interaction <0.05). CONCLUSIONS: LE8 and its subscale scores were positively associated with serum klotho levels in the middle-aged and older populations. Promoting the maintenance of ideal CVH can contribute to delaying the aging process.
目的：保持理想的心血管健康（CVH）被认为具有潜在的抗衰老益处。美国心脏协会（AHA）最近更新了“生命的八项基本要素（LE8）”指标来衡量理想的 CVH，但它与抗衰老蛋白 klotho 的关系仍不清楚。我们旨在探讨在具有全国代表性的美国中年和老年人中，理想心血管健康与血清抗衰老蛋白 klotho 之间的关系。 设计：横断面研究。 地点：国家健康和营养检查调查（2007-2016 年）。 参与者：共有 9457 名中年和老年人参加。 测量：根据 AHA 制定的指南定义理想的 CVH 评分及其组成部分。通过酶联免疫吸附测定法检测血清 klotho。采用加权多变量线性回归和限制三次样条分析 CVH 评分与 klotho 之间的关联。在完全调整的模型中，按年龄（40-59 岁和 60-79 岁）、性别（男性和女性）、种族（墨西哥裔美国人、非西班牙裔白人、非西班牙裔黑人、和其他人）和慢性肾脏疾病（是和否）进行亚组分析。 结果：本研究共纳入 9457 名中年和老年人，平均年龄为 55.27±0.17 岁。人群中血清 klotho 水平的平均值为 849.33±5.39pg/mL。在控制潜在混杂因素后，LE8 评分与血清 klotho 水平呈正相关（β：1.32；95%CI 0.73，1.91），并观察到非线性剂量反应关系。此外，我们还发现健康行为评分和健康因素评分与血清 klotho 水平呈正相关（β：0.48；95%CI 0.07，0.88 和 β：1.05；95%CI 0.54，1.56），特别是健康因素与血清 klotho 之间的相关性更强。在亚组分析中，我们观察到 LE8 评分与性别和种族之间存在显著的交互作用（P<0.05）。 结论：LE8 及其子量表评分与中年和老年人的血清 klotho 水平呈正相关。促进理想 CVH 的维持有助于延缓衰老过程。
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Zotero 插件