Department of Hepatology and Infectious Diseases, the First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, China.
Department of Hepatology, Ningbo No.2 Hospital, Ningbo, Zhejiang, China.
Sci Rep. 2024 Oct 28;14(1):25724. doi: 10.1038/s41598-024-76922-9.
We aim to evaluate the prevalence of steatotic liver disease (SLD) in United States (US) adolescents and explore whether metabolic dysfunction-associated steatotic liver disease (MASLD) can identify individuals with clinically significant fibrosis (CSF) in this study. The prevalence of SLD and its categories, including MASLD, metabolic dysfunction and alcohol associated liver disease (MetALD), alcohol related liver disease (ALD) and other SLD were determined. Weighted multivariable logistic regression analysis was conducted to evaluate the association between MASLD and CSF in adolescents with SLD. Among the total 1,446 US adolescents, SLD was present in 291 (20.1%) of individuals, including 260 (17.9%) for MASLD, 9 (0.6%) for MetALD and 5 (0.3%) for ALD. Only 58 (4%) had CSF. Patients with SLD showed a higher prevalence of CSF (9.6% vs. 2.6%, p < 0.001). Among patients with SLD, 89.3% met the MASLD criteria. The risk of CSF in patients with MASLD was not significantly different (odds ratio [OR] = 1.07, 95% confidence interval [CI] = 0.30-3.83, p = 0.9180) compared with those without MASLD. MASLD was met by most of the US adolescents with SLD. Moreover, MASLD was not associated with higher prevalence of CSF among adolescents with SLD.
本研究旨在评估美国青少年中脂肪性肝病（SLD）的流行情况，并探讨代谢相关脂肪性肝病（MASLD）是否可以识别出此类患者中存在临床显著纤维化（CSF）的个体。确定了 SLD 及其各分类（包括 MASLD、代谢功能障碍和酒精性肝病（MetALD）、ALD 和其他 SLD）的流行情况。采用加权多变量逻辑回归分析评估了 MASLD 与 SLD 青少年中 CSF 之间的相关性。在总共 1446 名美国青少年中，有 291 名（20.1%）存在 SLD，其中 260 名（17.9%）为 MASLD，9 名（0.6%）为 MetALD，5 名（0.3%）为 ALD。仅有 58 名（4%）存在 CSF。患有 SLD 的患者 CSF 发生率更高（9.6%比 2.6%，p<0.001）。在患有 SLD 的患者中，89.3%符合 MASLD 标准。患有 MASLD 的患者发生 CSF 的风险与未患有 MASLD 的患者无显著差异（比值比[OR] = 1.07，95%置信区间[CI] = 0.30-3.83，p = 0.9180）。大多数患有 SLD 的美国青少年符合 MASLD 标准。此外，在患有 SLD 的青少年中，MASLD 与 CSF 发生率升高无关。
