Department of Medicine, College of Medicine, King Khalid University, Abha, Saudi Arabia.
Department of Medicine, King Khalid University, Abha, Saudi Arabia.
BMC Cardiovasc Disord. 2024 Oct 28;24(1):600. doi: 10.1186/s12872-024-04254-7.
Type-D personality is an established predisposing factor for various diseases. Type-D traits have been shown to pose a 26% increased risk of coronary artery disease after controlling for other confounding factors. Significant associations have been reported between type-D personality traits and dyslipidaemia, impaired endothelial function, coronary heart disease (CAD), acute myocardial infarction, and other adverse cardiovascular events.
To assess the association between type-D personality and left-ventricular adverse remodelling in patients treated with percutaneous coronary intervention following index ST-segment elevation myocardial infarction.
All patients hospitalized and treated with percutaneous coronary intervention (PCI) after their index ST-segment elevation myocardial infarction (STEMI) between 1 January 2022 to 31 December 2023 were prospectively enrolled. Type-D personality traits in the study population were determined at baseline using type-D Scale-14 (DS14) instrument, whereas any positive change in left ventricular end diastolic volume (LVEDV) ≥ 20% at follow up period of 12-months from baseline was defined as left-ventricular adverse remodelling (LVAR). Univariate and multivariate analysis was done to establish the independent predictors of LVAR. The area under receiver-operating characteristic curve (AUROC) was employed to assess the sensitivity and specificity of the identified independent predictors.
A total of 124 patients were enrolled in the study. The mean age of the study population was 67 ± 10 years and the overall incidence of LVAR was found to be 25%. Multivariate regression analysis revealed that type-D personality is a significant independent predictor of LVAR [Formula: see text] apart from the already established independent predictors Killip Class[Formula: see text], baseline Global Longitudinal strain (GLS)[Formula: see text], and 3-vessel CAD[Formula: see text]. In ROC curve analysis type-D personality as an independent predictor of LVAR achieved a sensitivity of 41.4% and a specificity of 87.1%, p < 0.02.
Type-D personality trait is a significant independent predictor of LVAR in patients treated with PCI after their index-STEMI.
D 型人格是各种疾病的既定诱发因素。在控制其他混杂因素后，D 型特征已显示出患冠状动脉疾病的风险增加 26%。D 型人格特征与血脂异常、内皮功能障碍、冠心病（CAD）、急性心肌梗死和其他不良心血管事件之间存在显著关联。
评估 D 型人格与经皮冠状动脉介入治疗（PCI）后指数 ST 段抬高心肌梗死患者左心室不良重构之间的相关性。
前瞻性纳入 2022 年 1 月 1 日至 2023 年 12 月 31 日期间接受经皮冠状动脉介入治疗（PCI）的所有住院和接受经皮冠状动脉介入治疗（PCI）的患者指数 ST 段抬高心肌梗死（STEMI）后。在基线时使用 D 型量表-14（DS14）仪器确定研究人群中的 D 型人格特征，而在基线后 12 个月的随访期间，左心室舒张末期容积（LVEDV）的任何阳性变化≥20%定义为左心室不良重构（LVAR）。进行单变量和多变量分析以确定 LVAR 的独立预测因子。采用受试者工作特征曲线（AUROC）评估所确定的独立预测因子的敏感性和特异性。
共纳入 124 例患者。研究人群的平均年龄为 67±10 岁，LVAR 的总体发生率为 25%。多变量回归分析显示，除了已确立的独立预测因子 Killip 分级[Formula: see text]、基线整体纵向应变（GLS）[Formula: see text]和 3 支血管 CAD[Formula: see text]外，D 型人格也是 LVAR 的显著独立预测因子[Formula: see text]。在 ROC 曲线分析中，作为独立预测因子的 D 型人格对 LVAR 的敏感性为 41.4%，特异性为 87.1%，p<0.02。
在经皮冠状动脉介入治疗（PCI）后接受指数 STEMI 治疗的患者中，D 型人格特征是左心室不良重构的重要独立预测因子。
