Vierucci A, De Martino M, Di Palma A, Novembre E, Rossi M E, Resti M, Azzari C
Ann Allergy. 1986 Feb;56(2):158-61.
Positive skin tests to common inhalant allergens and the frequency of respiratory atopic diseases were determined in a population of multitransfused beta-thalassemic patients and in their parents and siblings. Positive skin test responses and respiratory atopic diseases were significantly less frequent in patients than in their relatives and in controls. Negative patients differed from positive patients as to the age at first transfusion, since the former had started transfusion earlier than the latter. It is speculated that in beta-thalassemic patients, allergen-specific IgG acquired early in life through transfusions suppresses the synthesis of allergen-specific IgE.
对一组多次输血的β地中海贫血患者及其父母和兄弟姐妹进行了常见吸入性过敏原皮肤试验阳性率及呼吸道过敏性疾病的发病率测定。患者的皮肤试验阳性反应及呼吸道过敏性疾病的发病率显著低于其亲属和对照组。阴性患者与阳性患者在首次输血年龄上存在差异，前者开始输血的时间早于后者。据推测，在β地中海贫血患者中，早期通过输血获得的过敏原特异性IgG会抑制过敏原特异性IgE的合成。
