Xie Yuxin, Wu Feng, Chen Zhe, Hou Yu
Department of Radiological Medicine, School of Basic Medical Sciences, Chongqing Medical University, Chongqing, 400016, China.
Biomark Med. 2024;18(21-22):995-1005. doi: 10.1080/17520363.2024.2416887. Epub 2024 Oct 29.
Epithelial membrane protein 1 (EMP1) is a member of the small hydrophobic membrane protein subfamily. EMP1 is aberrantly expressed in various tumor tissues and governs multiple cellular behaviors (e.g., proliferation, differentiation, and migration). The resultant regulation of the cancer pathway is responsible for the metastasis of cancer cells and determines the risk of malignant tumor progression. This review provides an updated overview of EMP1 as either an oncogene or a tumor suppressor contingent on the cancer type and summarizes its upstream regulators and downstream target genes. This systematic review summarizes our current understanding of the role of EMP1 in malignant tumor development, including critical functional mechanisms and implications for its potential use as the biomarker and therapeutic target.
上皮膜蛋白1（EMP1）是小疏水膜蛋白亚家族的成员。EMP1在多种肿瘤组织中异常表达，并调控多种细胞行为（如增殖、分化和迁移）。由此对癌症通路的调控导致癌细胞转移，并决定恶性肿瘤进展的风险。本综述提供了关于EMP1作为癌基因或肿瘤抑制因子（取决于癌症类型）的最新概述，并总结了其上游调节因子和下游靶基因。本系统综述总结了我们目前对EMP1在恶性肿瘤发展中的作用的理解，包括关键的功能机制及其作为生物标志物和治疗靶点的潜在用途。
