Department of Pharmacology, UT Southwestern Medical Center, Dallas, TX 75390, USA.
Department of Molecular Genetics, UT Southwestern Medical Center, Dallas, TX 75390, USA.
Chem Commun (Camb). 2024 Nov 14;60(92):13534-13537. doi: 10.1039/d4cc04393f.
We synthesized a WNT5A β-hairpin peptide responsible for the protein's binding to its receptor, Frizzled. Full affinity to Frizzled requires all three disulfides but not an invariant tryptophan that significantly contributes to the buried surface area. Our work opens the avenue to target the Wnt-Fzd interface using synthetic peptides.
我们合成了一个 WNT5A β-发夹肽，该肽负责蛋白质与其受体 Frizzled 的结合。与 Frizzled 完全结合需要所有三个二硫键，但不需要一个不变的色氨酸，因为该色氨酸对埋藏表面积有重要贡献。我们的工作为使用合成肽靶向 Wnt-Fzd 界面开辟了道路。
