Cooper J C, Williams N S
Ann R Coll Surg Engl. 1986 Jan;68(1):23-6.
One hundred and forty-two patients with Crohn's disease, undergoing 154 resections and reanastomoses, were reviewed to evaluate the influence of residual microscopic Crohn's disease at the margin of resection on recurrence. Sixty-three cases had microscopic evidence of disease at the resection margin (group I), and 91 cases had disease-free margins (group II). Of the survivors 125 patients undergoing 136 operations were reviewed. Median follow-up was 6.0 years (range 0.25-16 years) in group I, and 5.5 years (range 0.25-14.5 years) in group II. Twenty-two of 57 cases (38%) in group I developed recurrence compared with 23 of 79 cases (29%) in group II (P-NS). Cumulative recurrence rates at 10 years were 66.5% and 58% respectively (P-NS). The results support the increasing evidence that the presence of microscopic disease at the resection margin does not adversely affect recurrence in Crohn's disease.
对142例接受了154次切除和再吻合术的克罗恩病患者进行了回顾性研究，以评估切除边缘残留的微小克罗恩病对复发的影响。63例在切除边缘有疾病的微观证据（I组），91例切除边缘无疾病（II组）。对125例接受了136次手术的存活患者进行了回顾。I组的中位随访时间为6.0年（范围0.25 - 16年），II组为5.5年（范围0.25 - 14.5年）。I组57例中的22例（38%）出现复发，而II组79例中的23例（29%）出现复发（P值无统计学意义）。10年时的累积复发率分别为66.5%和58%（P值无统计学意义）。这些结果支持了越来越多的证据，即切除边缘存在微小疾病不会对克罗恩病的复发产生不利影响。
