Department of Neurology, Jiangxi Provincial People's Hospital, Clinical College of Nanchang Medical College, First Affiliated Hospital of Nanchang Medical College, National Regional Medical Center for Neurological Diseases, Xiangya Hospital of Central South University Jiangxi Hospital, Nanchang, Jiangxi, China.
Ann Med. 2024 Dec;56(1):2422572. doi: 10.1080/07853890.2024.2422572. Epub 2024 Oct 29.
The nomenclature of amyotrophic lateral sclerosis (ALS) currently is blurred, indistinct and no accurate and haven't been properly updated since the first description, which is far from being suitable for the current implementation of clinical practise and scientific research of ALS, and urgently need an solution. Furthermore, the current diagnostic criteria need also further been improved, because the current clinical diagnosis of ALS majorly depends on the clinical manifestations yet. Up to now, no any objective clinical auxiliary examination can be helpful to diagnose ALS besides the electromyogram identifying the lower motor neuron damage, which isn't conducive to early diagnosis and prolongs the time of ALS confirmed diagnosis. In this mini review, we discussed the current doubt about the nomenclature and diagnostic criteria of ALS, and prospected in order to further improve and normalize the nomenclature and diagnosis of ALS.
肌萎缩侧索硬化症（ALS）的命名目前较为模糊、不明确，且自首次描述以来一直没有得到准确更新，远不能适应目前 ALS 的临床实践和科学研究，急需解决。此外，目前的诊断标准也需要进一步改进，因为目前 ALS 的临床诊断主要依赖于临床表现。迄今为止，除了肌电图识别下运动神经元损伤外，没有任何客观的临床辅助检查有助于诊断 ALS，这不利于早期诊断，延长了 ALS 确诊的时间。在这篇综述中，我们讨论了目前对 ALS 命名和诊断标准的质疑，并展望了进一步完善和规范 ALS 命名和诊断的方向。
