Department of Pathology, Yueyang Central Hospital, Yueyang City, Hunan Province, China.
Department of Pathology, Weifang People's Hospital (First Affiliated Hospital of Shandong Second Medical University), Weifang City, Shandong Province, China.
Medicine (Baltimore). 2024 Oct 25;103(43):e40149. doi: 10.1097/MD.0000000000040149.
Cervical gastric-type adenocarcinoma shows gastric differentiation, and the tumor cell morphology appears benign and unrelated to human papillomavirus, which makes cervical gastric-type adenocarcinoma highly susceptible to misdiagnosis as normal glandular epithelium in cytologic diagnosis.
We present 3 cases of gastric-type adenocarcinoma, with the first being a 57-year-old female with abnormal uterine bleeding and fluid drainage. The second patient was a 63-year-old female, and the third was a 59-year-old female with irregular vaginal bleeding after menopause.
The 3 patients were diagnosed with cervical gastric-type adenocarcinoma by combining their history, clinical data, cytopathology, histopathology, and immunohistochemistry.
Patient 1 underwent total hysterectomy and adnexectomy, but refused radiotherapy and chemotherapy. Patient 2 received a chemotherapeutic regimen, and patient 3 was treated with traditional Chinese medicine.
Patient 1 was followed-up for 9 months and is currently in good general condition, while patients 2 and 3 were not followed-up.
The "drunken honeycomb" cell arrangement is diagnostically important in liquid-based cytology, especially when three-dimensional spheroids are present, and may be a characteristic cytological finding of well-differentiated cervical gastric-type adenocarcinoma.
宫颈胃型腺癌显示胃分化，肿瘤细胞形态呈良性，与人类乳头瘤病毒无关，这使得宫颈胃型腺癌在细胞学诊断中极易被误诊为正常腺上皮。
我们报告了 3 例胃型腺癌病例，第 1 例为 57 岁女性，表现为异常子宫出血和液体排出；第 2 例为 63 岁女性，第 3 例为 59 岁绝经后不规则阴道出血女性。
3 例患者均结合病史、临床资料、液基细胞学、组织病理学和免疫组织化学检查诊断为宫颈胃型腺癌。
患者 1 行全子宫及附件切除术，但拒绝放化疗；患者 2 接受化疗方案，患者 3 接受中药治疗。
患者 1 随访 9 个月，目前一般情况良好，而患者 2 和 3 未随访。
“醉酒样蜂窝”细胞排列在液基细胞学检查中具有重要的诊断价值，特别是当存在三维球体时，可能是分化良好的宫颈胃型腺癌的特征性细胞学发现。
