胃型宫颈内膜腺癌：全面的细胞病理学分析，并与普通型宫颈内膜腺癌进行比较。
Gastric-type Endocervical Adenocarcinoma: Comprehensive Cytopathological Analysis and Comparison With Usual-type Endocervical Adenocarcinoma.
机构信息
Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
Department of Pathology and Translational Genomics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
出版信息
In Vivo. 2023 May-Jun;37(3):1173-1181. doi: 10.21873/invivo.13192.
BACKGROUND/AIM: Gastric-type endocervical adenocarcinoma (GEA) is a rare but distinct histological type of gynecological malignancy. This study aimed to conduct a comprehensive analysis of the cytological features of GEA.
PATIENTS AND METHODS
We reviewed 18 cytological samples obtained from 14 patients with GEA. All cytology slides were prepared using conventional smear and liquid-based preparations. We examined the differences between the cytological features of GEA and usual-type endocervical adenocarcinoma (UEA).
RESULTS
The cytological samples of GEA exhibited flat, honeycomb-like cellular sheets (p=0.035), vesicular nuclei (p=0.037) with prominent nucleoli (p=0.037), and vacuolated cytoplasm (p<0.001) more frequently than those of UEA, irrespective of the sampling site and preparation method. UEA showed three-dimensional cellular clusters (p<0.001), peripheral nuclear feathering (p<0.001), and nuclear hyperchromasia (p=0.014) more frequently than GEA.
CONCLUSION
GEA can be identified cytologically based on the presence of flat, honeycomb-like sheets of tumor cells possessing vesicular nuclei, prominent nucleoli, and abundant vacuolated cytoplasm.
背景/目的：胃型宫颈内膜腺癌（GEA）是一种罕见但具有独特组织学特征的妇科恶性肿瘤。本研究旨在对 GEA 的细胞学特征进行全面分析。
患者与方法
我们回顾了 14 例 GEA 患者的 18 例细胞学样本。所有细胞学涂片均采用传统涂片和液基制备方法制备。我们比较了 GEA 和普通型宫颈内膜腺癌（UEA）的细胞学特征。
结果
GEA 的细胞学样本表现为扁平、蜂窝状的细胞片（p=0.035）、泡状核（p=0.037）伴明显核仁（p=0.037）和空泡状细胞质（p<0.001），比 UEA 更常见，与采样部位和制备方法无关。UEA 比 GEA 更常表现为三维细胞簇（p<0.001）、核周羽毛状（p<0.001）和核深染（p=0.014）。
结论
基于存在扁平、蜂窝状的肿瘤细胞，具有泡状核、明显核仁及丰富空泡状细胞质，可对 GEA 进行细胞学诊断。
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