González-Nuñez Carlos, Mohar Alejandro, Reynoso-Noverón Nancy, Alvarez-Gómez Rosa María, Chavarri-Guerra Yanin, Aguilar-Villanueva Sergio, Guzmán-Trigueros Raúl, Velázquez-Martínez Areli, Wegman-Ostrosky Talía, Porras-Reyes Fanny, Garcilazo Alexandra, Arce Claudia, Bargallo-Rocha Juan Enrique, Cabrera-Galeana Paula
Breast Medical Oncology Unit, Instituto Nacional de Cancerología, Mexico City, Mexico.
Epidemiology Unit, Instituto Nacional de Cancerología e Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico City, Mexico.
Breast Cancer Res Treat. 2025 Feb;209(3):629-635. doi: 10.1007/s10549-024-07525-1. Epub 2024 Oct 29.
Breast cancer is the most prevalent cancer type in Mexico, with male breast cancer accounting for only 1% of all breast cancer cases. A limited number of studies have described the clinical-pathological profiles of males with breast cancer in low- and middle-income countries. This study presents an analysis of patients with breast cancer seen at three different institutions in México.
A retrospective review of the medical records was performed to analyze the clinical and pathological characteristics of 49 men diagnosed with breast cancer and their overall survival.
The mean age at diagnosis was 64.65 years. A significant proportion of patients presented at diagnosis with stage IV disease (n = 11, 22.45%), had triple-negative subtype (n = 6, 12.24%), and nuclear grade III (n = 20, 40.8%). Primary endocrine resistance was observed in 10 patients (31.25%). Genetic analysis was performed on 24 patients (48.9%), revealing a germline BRCA pathogenic variant in 8.33%.
Our findings described the clinical and pathological profile of breast cancer in a male cohort in Mexico, with a significantly high proportion of advanced disease, triple-negative subtype, nuclear grade III, and endocrine resistance. Further comprehensive studies, including research into somatic mutations, are needed.
乳腺癌是墨西哥最常见的癌症类型，男性乳腺癌仅占所有乳腺癌病例的1%。在低收入和中等收入国家，仅有少数研究描述了男性乳腺癌患者的临床病理特征。本研究对墨西哥三个不同机构收治的乳腺癌患者进行了分析。
对病历进行回顾性分析，以分析49例诊断为乳腺癌的男性患者的临床和病理特征及其总生存期。
诊断时的平均年龄为64.65岁。相当一部分患者在诊断时已处于IV期疾病（n = 11，22.45%），具有三阴性亚型（n = 6，12.24%），核分级为III级（n = 20，40.8%）。10例患者（31.25%）观察到原发性内分泌抵抗。对24例患者（48.9%）进行了基因分析，发现8.33%的患者存在种系BRCA致病变异。
我们的研究结果描述了墨西哥男性乳腺癌患者的临床和病理特征，其中晚期疾病、三阴性亚型、核分级III级和内分泌抵抗的比例显著较高。需要进一步进行全面研究，包括对体细胞突变的研究。
