Wang Xiang, Wang Xiao-Qing, Luo Kai, Bai He, Qi Jia-Lin, Zhang Gui-Xin
Department of General Surgery, the Second Hospital of Dalian Medical University, Dalian, Liaoning Province, 116027, China.
Clinical Laboratory of Integrative Medicine, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning Province, 116021, China.
Chin J Integr Med. 2025 Feb;31(2):170-182. doi: 10.1007/s11655-024-4203-9. Epub 2024 Oct 29.
Cholangiocarcinoma (CCA) is a malignant tumor originating from cholangiocytes. However, it remains unclear about the pathogenesis of this carcinoma, which may be related to multiple factors. Currently, CCA is mainly treated by surgery, chemotherapy, and radiotherapy. Among them, surgery is the only potentially curative option for CCA. Nevertheless, the high malignancy and asymptomatic nature of CCA may lead to poor treatment outcomes. It has been demonstrated that Chinese medicine (CM) plays a significant role in various antitumor applications. Meanwhile, CM exhibits fewer side effects and high availability. Moreover, the in vitro application of CM monomers has been explored in many domestic and foreign studies. This article mainly reviews the signaling pathways and molecular mechanisms of CM monomers in the treatment of CCA in recent years. These findings are expected to provide new insights into the treatment of CCA.
胆管癌（CCA）是一种起源于胆管上皮细胞的恶性肿瘤。然而，这种癌症的发病机制仍不清楚，可能与多种因素有关。目前，CCA主要通过手术、化疗和放疗进行治疗。其中，手术是CCA唯一可能治愈的选择。然而，CCA的高恶性和无症状性质可能导致治疗效果不佳。已有研究表明，中药在各种抗肿瘤应用中发挥着重要作用。同时，中药副作用较少且可用性高。此外，国内外许多研究都对中药单体的体外应用进行了探索。本文主要综述了近年来中药单体治疗CCA的信号通路和分子机制。这些研究结果有望为CCA的治疗提供新的见解。
