长链非编码RNA作为妊娠期糖尿病妊娠结局生物标志物的价值：一项荟萃分析。

The value of lncRNAs as a biomarker for the pregnancy outcomes of gestational diabetes: a meta-analysis.

作者信息

Bao Chunling, Kuang Jun, He Chuanyong, Xu Hui

机构信息

Department of Obstetrics and Gynecology, The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, No.158, Wuyang Avenue, Enshi, 445000, China.

出版信息

Ir J Med Sci. 2025 Feb;194(1):91-100. doi: 10.1007/s11845-024-03828-w. Epub 2024 Oct 29.

DOI:10.1007/s11845-024-03828-w

PMID:39470971

Abstract

BACKGROUND

Long non-coding RNAs (lncRNAs) are tissue-specific and highly stable and may serve as early molecular markers of adverse pregnancy outcomes in patients with gestational diabetes mellitus (GDM).

AIMS

This study aimed to investigate the relationship between aberrant expression of lncRNAs and adverse pregnancy outcomes in GDM patients.

METHODS

We searched electronic databases: Embase, Medline, EBSCO, PubMed, CNKI, and Wanfang databases to find relevant articles. Included studies quality was assessed using the QUADAS-2 quality assessment tool. Prognostic value of lncRNAs were pooled using risk ratio (RR) with 95% confidence interval (95%CI). The heterogeneity was analyzed using the Cochran Q test and I statistical test, and subgroup analyses were performed to explore the sources of heterogeneity. Begg's test funnel plots were analyzed for publication bias.

RESULTS

The review included nine studies. Overall, the review found that altered expression of lncRNAs was associated with adverse pregnancy outcomes of GDM patients (RR: 1.616, 95%CI: 1.308-1.996), and was a risk factor for adverse pregnancy outcomes both of Infants (RR: 1.68, 95% CI: 1.30-2.17) and maternal (RR: 4.14, 95% CI: 1.90-9.03) in patients with GDM. The diagnostic procedure, diagnostic criteria, expression trend of lncRNAs, and adverse pregnancy outcomes were the sources of heterogeneity.

CONCLUSIONS

Aberrant expression of lncRNAs was strongly associated with the adverse pregnancy outcomes in GDM.

摘要

背景

长链非编码RNA（lncRNAs）具有组织特异性且高度稳定，可能作为妊娠期糖尿病（GDM）患者不良妊娠结局的早期分子标志物。

目的

本研究旨在探讨lncRNAs异常表达与GDM患者不良妊娠结局之间的关系。

方法

我们检索了电子数据库：Embase、Medline、EBSCO、PubMed、中国知网（CNKI）和万方数据库，以查找相关文章。使用QUADAS-2质量评估工具评估纳入研究的质量。采用风险比（RR）及95%置信区间（95%CI）汇总lncRNAs的预后价值。使用Cochran Q检验和I统计检验分析异质性，并进行亚组分析以探索异质性来源。分析Begg检验漏斗图以评估发表偏倚。

结果

该综述纳入了9项研究。总体而言，该综述发现lncRNAs表达改变与GDM患者的不良妊娠结局相关（RR：1.616，95%CI：1.308 - 1.996），并且是GDM患者婴儿（RR：1.68，95%CI：1.30 - 2.17）和母亲（RR：4.14，95%CI：1.90 - 9.03）不良妊娠结局的危险因素。诊断程序、诊断标准、lncRNAs的表达趋势和不良妊娠结局是异质性的来源。