Parkin Rebecca, Bennett Kathleen, Mc Nicholas Fiona, Hayden John C
School of Pharmacy and Biomolecular Sciences, RCSI University of Medicine and Health Sciences, Dublin, Ireland.
Data Science Centre, School of Population Health, RCSI University of Medicine and Health Sciences, Dublin, Ireland.
Int J Clin Pharm. 2025 Feb;47(1):146-156. doi: 10.1007/s11096-024-01817-8. Epub 2024 Oct 29.
There has been a global rise in prescribing of psychotropic medications. Variations in patterns of use, according to age, gender and drug class type, have also been reported.
This study aimed to analyse patterns of psychotropic medication use in Ireland according to age group, gender and drug class type, to determine if variations exist, and identify specific nuances to be addressed in future research.
A retrospective, repeated, cross-sectional study of the Irish pharmacy claims database (community setting dispensing data) was conducted. Yearly prevalence of children/adolescents receiving dispensed psychotropic medications was analysed from January 2017 to December 2021, across years, age groups (5-15, 5-11 and 12-15 years), gender and drug class type. All available data were used. Yearly prevalence was the mean number of patients receiving medication per month per 1000 eligible population during a given year. Negative binomial regression was used to examine association of year, age group and gender on prevalence.
In the 12-15 years group, prevalence for all selected psychotropic medications in 2021 in males was almost twice that in females (19.92/1000 vs 10.62/1000). In the 5-11 years group, prevalence was three times higher in males than females (7.56/1000 vs 2.49/1000). Overall, there was a higher rate of increase in females and higher usage in older children.
This study found variations in psychotropic medication use in children/adolescents, depending on age, gender and drug class type. Further research is needed to determine whether variations have resulted in treatment disparities for certain cohorts.
全球范围内精神类药物的处方量呈上升趋势。据报道,根据年龄、性别和药物类别,用药模式也存在差异。
本研究旨在分析爱尔兰按年龄组、性别和药物类别划分的精神类药物使用模式,以确定是否存在差异,并识别未来研究中需要解决的具体细微差别。
对爱尔兰药房索赔数据库(社区药房配药数据)进行了一项回顾性、重复性横断面研究。分析了2017年1月至2021年12月期间,各年份、年龄组(5 - 15岁、5 - 11岁和12 - 15岁)、性别和药物类别下,接受配给精神类药物的儿童/青少年的年患病率。使用了所有可用数据。年患病率是给定年份中每1000名符合条件人群每月接受药物治疗的患者平均人数。采用负二项回归分析年份、年龄组和性别与患病率之间的关联。
在12 - 15岁年龄组中,2021年所有选定精神类药物的男性患病率几乎是女性的两倍(19.92/1000对10.62/1000)。在5 - 11岁年龄组中,男性患病率是女性的三倍(7.56/1000对2.49/1000)。总体而言,女性的增长率较高,年龄较大的儿童用药量较高。
本研究发现儿童/青少年精神类药物的使用存在差异,具体取决于年龄、性别和药物类别。需要进一步研究以确定这些差异是否导致某些队列出现治疗差异。