Beilharz Sophia, Debnath Mithun Kumar, Vinella Daniele, Shoffstall Andrew J, Karayilan Metin
Department of Chemistry, Case Western Reserve University, Cleveland, Ohio 44106, United States.
Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio 44106, United States.
ACS Appl Bio Mater. 2024 Dec 16;7(12):8076-8101. doi: 10.1021/acsabm.4c01001. Epub 2024 Oct 29.
Injectable biomaterials have been engineered to operate within the human body, offering versatile solutions for minimally invasive therapies and meeting several stringent requirements such as biocompatibility, biodegradability, low viscosity for ease of injection, mechanical strength, rapid gelation postinjection, controlled release of therapeutic agents, hydrophobicity/hydrophilicity balance, stability under physiological conditions, and the ability to be sterilized. Their adaptability and performance in diverse clinical settings make them invaluable for modern medical treatments. This article reviews recent advancements in the design, synthesis, and characterization of injectable polymeric biomaterials, providing insights into their emerging applications. We discuss a broad spectrum of these materials, including natural, synthetic, hybrid, and composite types, that are being applied in targeted drug delivery, cell and protein transport, regenerative medicine, tissue adhesives, injectable implants, bioimaging, diagnostics, and 3D bioprinting. Ultimately, the review highlights the critical role of injectable polymeric biomaterials in shaping the future of medical treatments and improving patient outcomes across a wide range of therapeutic and diagnostic applications.
可注射生物材料已被设计用于在人体内发挥作用，为微创治疗提供了多种解决方案，并满足了多项严格要求，如生物相容性、生物降解性、便于注射的低粘度、机械强度、注射后快速凝胶化、治疗剂的控释、疏水性/亲水性平衡、生理条件下的稳定性以及可灭菌的能力。它们在不同临床环境中的适应性和性能使其在现代医学治疗中具有极高价值。本文综述了可注射聚合物生物材料在设计、合成和表征方面的最新进展，深入探讨了它们的新兴应用。我们讨论了广泛的这类材料，包括天然、合成、混合和复合类型，它们正被应用于靶向药物递送、细胞和蛋白质运输、再生医学、组织粘合剂、可注射植入物、生物成像、诊断以及3D生物打印。最终，该综述强调了可注射聚合物生物材料在塑造医学治疗未来以及改善广泛治疗和诊断应用中的患者预后方面的关键作用。
