用于生物医学应用的可生物降解聚合物材料的当前发展状况。
Current development of biodegradable polymeric materials for biomedical applications.
作者信息
Song Richard, Murphy Maxwell, Li Chenshuang, Ting Kang, Soo Chia, Zheng Zhong
机构信息
Division of Growth and Development, Section of Orthodontics, School of Dentistry, University of California, Los Angeles, Los Angeles, CA, USA,
UCLA Department of Surgery and Department of Orthopaedic Surgery and The Orthopaedic Hospital Research Center, University of California, Los Angeles, Los Angeles, CA, USA,
出版信息
Drug Des Devel Ther. 2018 Sep 24;12:3117-3145. doi: 10.2147/DDDT.S165440. eCollection 2018.
In the last half-century, the development of biodegradable polymeric materials for biomedical applications has advanced significantly. Biodegradable polymeric materials are favored in the development of therapeutic devices, including temporary implants and three-dimensional scaffolds for tissue engineering. Further advancements have occurred in the utilization of biodegradable polymeric materials for pharmacological applications such as delivery vehicles for controlled/sustained drug release. These applications require particular physicochemical, biological, and degradation properties of the materials to deliver effective therapy. As a result, a wide range of natural or synthetic polymers able to undergo hydrolytic or enzymatic degradation is being studied for biomedical applications. This review outlines the current development of biodegradable natural and synthetic polymeric materials for various biomedical applications, including tissue engineering, temporary implants, wound healing, and drug delivery.
在过去的半个世纪里，用于生物医学应用的可生物降解聚合物材料取得了显著进展。可生物降解聚合物材料在治疗器械的开发中受到青睐，包括临时植入物和用于组织工程的三维支架。在将可生物降解聚合物材料用于药物应用（如控制/持续药物释放的递送载体）方面也有了进一步的进展。这些应用要求材料具有特定的物理化学、生物学和降解特性，以提供有效的治疗。因此，正在研究各种能够进行水解或酶解降解的天然或合成聚合物用于生物医学应用。本综述概述了用于各种生物医学应用（包括组织工程、临时植入物、伤口愈合和药物递送）的可生物降解天然和合成聚合物材料的当前发展情况。
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