Medical Genetics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Medical Genetics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Pathol Res Pract. 2024 Nov;263:155683. doi: 10.1016/j.prp.2024.155683. Epub 2024 Oct 28.
Tumor cell invasion is considered as one of the main therapeutic challenges in cancer patients, which leads to distant metastasis and reduced prognosis. Therefore, investigation of the factors involved in tumor cell invasion improves the therapeutic methods to reduce tumor metastasis. Epithelial-mesenchymal transition (EMT) process has a pivotal role in tumor cell invasion and metastasis, during which tumor cells gain the invasive ability by losing epithelial characteristics and acquiring mesenchymal characteristics. WNT/β-catenin signaling pathway has a key role in tumor cell invasion by regulation of EMT process. Long non-coding RNAs (lncRNAs) have also an important role in EMT process through the regulation of WNT/β-catenin pathway. Deregulation of lncRNAs is associated with tumor metastasis in different tumor types. Therefore, in the present review, we investigated the role of lncRNAs in EMT process and tumor cell invasion through the regulation of WNT/β-catenin pathway. It has been reported that lncRNAs mainly induced the EMT process and tumor cell invasion through the activation of WNT/β-catenin pathway. LncRNAs that regulate the WNT/β-catenin mediated EMT process can be introduced as the prognostic markers as well as suitable therapeutic targets to reduce the tumor metastasis in cancer patients.
肿瘤细胞的侵袭被认为是癌症患者治疗的主要挑战之一，它导致远处转移和预后降低。因此，研究肿瘤细胞侵袭相关的因素可以改善治疗方法，减少肿瘤转移。上皮-间充质转化（EMT）过程在肿瘤细胞的侵袭和转移中起着关键作用，在此过程中，肿瘤细胞通过失去上皮特征获得间充质特征而获得侵袭能力。WNT/β-catenin 信号通路通过调节 EMT 过程在肿瘤细胞侵袭中起着关键作用。长链非编码 RNA（lncRNA）也通过调节 WNT/β-catenin 通路在 EMT 过程中发挥重要作用。lncRNA 的失调与不同类型肿瘤的转移有关。因此，在本综述中，我们研究了 lncRNA 通过调节 WNT/β-catenin 通路在 EMT 过程和肿瘤细胞侵袭中的作用。据报道，lncRNA 主要通过激活 WNT/β-catenin 通路诱导 EMT 过程和肿瘤细胞侵袭。调节 WNT/β-catenin 介导的 EMT 过程的 lncRNA 可以作为预后标志物和合适的治疗靶点，以减少癌症患者的肿瘤转移。
