Wiegand Vanessa, Gao Ying, Teusch Nicole
Institute of Pharmaceutical Biology and Biotechnology, Heinrich Heine University Düsseldorf, Germany.
Planta Med. 2024 Dec;90(15):1115-1129. doi: 10.1055/a-2441-6488. Epub 2024 Oct 29.
Painful diabetic neuropathy (PDN) is a highly prevalent complication in patients suffering from diabetes mellitus. Given the inadequate pain-relieving effect of current therapies for PDN, there is a high unmet medical need for specialized therapeutic options. In traditional Chinese medicine (TCM), various herbal formulations have been implemented for centuries to relieve pain, and one commonly used plant in this context is (). Here, we summarize the chemical constituents of including their pharmacological mechanisms-of-action and discuss potential benefits for the treatment of PDN. For this, data, as well as preclinical and clinical studies, were critically reviewed and comprehensively compiled. Our findings reveal that and its individual constituents exhibit a variety of pharmacological properties relevant for PDN, including antinociceptive, anti-inflammatory, antioxidant, and antiapoptotic activities. Through this multifaceted and complex combination of various pharmacological effects, relevant hallmarks of PDN are specifically addressed, suggesting that may represent a promising source for novel therapeutic approaches for PDN.
痛性糖尿病神经病变（PDN）是糖尿病患者中一种非常普遍的并发症。鉴于目前PDN治疗方法的止痛效果不佳，对于专门的治疗选择存在高度未满足的医疗需求。在传统中医（TCM）中，各种草药配方已经使用了几个世纪来缓解疼痛，在这种情况下常用的一种植物是（此处原文缺失植物名称）。在此，我们总结了（此处原文缺失植物名称）的化学成分，包括其药理作用机制，并讨论其对PDN治疗的潜在益处。为此，对相关数据以及临床前和临床研究进行了严格审查和全面汇编。我们的研究结果表明，（此处原文缺失植物名称）及其单个成分表现出与PDN相关的多种药理特性，包括抗伤害感受、抗炎、抗氧化和抗凋亡活性。通过这种多种药理作用的多方面和复杂组合，PDN的相关特征得到了专门解决，这表明（此处原文缺失植物名称）可能是PDN新型治疗方法的一个有前景的来源。
