Yang Shangwei, Zheng Yanhe, Pu Zhenjun, Nian Hongyu, Li Junliang
Gansu University of Chinese Medicine, Lanzhou, China.
Digestive Department, The First People's Hospital of Lanzhou New Area, Lanzhou, China.
Immunol Cell Biol. 2025 Jan;103(1):31-44. doi: 10.1111/imcb.12831. Epub 2024 Oct 29.
Peritoneal adhesion (PA) refers to the abnormal adhesion of the peritoneum either with the peritoneum itself or with tissues and organs that is caused by abdominopelvic surgery, abdominal infection or peritoneal inflammation. PA is associated with various clinical complications, such as abdominal pain and distension, intestinal obstruction, gastrointestinal disorders and female infertility, and adversely affects the quality of life of patients. Macrophages are essential for PA formation and can undergo polarization into classically activated macrophages (M1) and alternatively activated macrophages (M2), which are influenced by the peritoneal microenvironment. By releasing proinflammatory cytokines and reactive oxygen species, M1 macrophages promote peritoneal inflammatory reactions and the resultant formation of adhesion. In contrast, M2 macrophages secrete anti-inflammatory cytokines and growth factors to inhibit PA formation and to promote repair and healing of peritoneal tissues, and thereby play a significant anti-inflammatory role. This review comprehensively explores the function and mechanism of macrophages and their subtypes in PA formation to gain insight into the prevention and treatment of PA based on the modulation of macrophages.
腹膜粘连（PA）是指由于腹部盆腔手术、腹部感染或腹膜炎症导致腹膜自身之间或与组织和器官之间的异常粘连。PA与各种临床并发症相关，如腹痛、腹胀、肠梗阻、胃肠功能紊乱和女性不孕，并对患者的生活质量产生不利影响。巨噬细胞对PA的形成至关重要，可极化为经典活化巨噬细胞（M1）和交替活化巨噬细胞（M2），这受到腹膜微环境的影响。M1巨噬细胞通过释放促炎细胞因子和活性氧促进腹膜炎症反应及随后的粘连形成。相反，M2巨噬细胞分泌抗炎细胞因子和生长因子以抑制PA形成并促进腹膜组织的修复和愈合，从而发挥显著的抗炎作用。本综述全面探讨巨噬细胞及其亚型在PA形成中的功能和机制，以期基于对巨噬细胞的调控深入了解PA的预防和治疗。
