O'Donovan Gary, Petermann-Rocha Fanny, Ferrari Gerson, Medina Catalina, Ochoa-Rosales Carolina, Sarmiento Olga L L, Ibáñez Agustín
Facultad de Medicina, Universidad de los Andes, Bogotá, Colombia
Centro de Investigación Biomédica, Facultad de Medicina, Universidad Diego Portales, Santiago, Chile.
Br J Sports Med. 2025 Feb 20;59(5):325-332. doi: 10.1136/bjsports-2024-108460.
To investigate associations of the 'weekend warrior' physical activity pattern with mild dementia.
Participants in the Mexico City Prospective Study were surveyed from 1998 to 2004 and re-surveyed from 2015 to 2019. Participants were asked about leisure time physical activity at baseline. Those who exercised up to once or twice per week were termed 'weekend warriors' and those who exercised more often were termed 'regularly active'. A Mini Mental State Examination (MMSE) was used to assess mild dementia at re-survey. Cox models were adjusted for age, sex, education, income, blood pressure, smoking, body mass index, civil status, sleep, diet and alcohol at baseline. The attributable fraction was defined as the proportion of cases that would not exist if all adults were to exercise once or twice per week or more often.
The analysis included 10 033 adults of mean (SD) age 51 (10) years followed for 16 (2) years. There were 2400 cases when mild dementia was defined as a score of ≤22 on the MMSE. Compared with the group that reported no sport or exercise, the hazard ratio was 0.75 (95% CI 0.61 to 0.91) in the weekend warrior group, 0.89 (95% CI 0.78 to 1.02) in the regularly active group and 0.84 (95% CI 0.75 to 0.95) in the combined group. The attributable fraction was 13% (95% CI 5% to 21%). Similar results were observed when mild dementia was defined as a score of ≤23 on the MMSE.
This longitudinal analysis suggests that the weekend warrior physical activity pattern is associated with a reduced risk of mild dementia.
研究“周末战士”身体活动模式与轻度痴呆之间的关联。
对墨西哥城前瞻性研究的参与者在1998年至2004年进行了调查，并在2015年至2019年进行了重新调查。在基线时询问参与者的休闲时间身体活动情况。那些每周锻炼一到两次的人被称为“周末战士”，而那些锻炼更频繁的人被称为“经常运动者”。在重新调查时使用简易精神状态检查表（MMSE）来评估轻度痴呆。Cox模型在基线时根据年龄、性别、教育程度、收入、血压、吸烟、体重指数、婚姻状况、睡眠、饮食和饮酒情况进行了调整。归因分数定义为如果所有成年人每周锻炼一到两次或更频繁，那么本不会出现的病例比例。
分析纳入了10033名平均（标准差）年龄为51（10）岁的成年人，随访了16（2）年。当轻度痴呆被定义为MMSE评分≤22分时，有2400例病例。与报告不进行任何运动的组相比，“周末战士”组的风险比为0.75（95%置信区间0.61至0.91），经常运动组为0.89（95%置信区间0.78至1.02），联合组为0.84（95%置信区间0.75至0.95）。归因分数为13%（95%置信区间5%至21%）。当轻度痴呆被定义为MMSE评分≤23分时，观察到了类似的结果。
这项纵向分析表明，“周末战士”身体活动模式与轻度痴呆风险降低有关。
