Pal Shibam, Gavhane Utreshwar Arjun, S K Asha
Polymer Science and Engineering Division, CSIR-National Chemical Laboratory, Dr. Homi Bhabha Road, Pashan, Pune 411008, Maharashtra, India.
Academy of Scientific and Innovative Research, Sector 19, Kamla Nehru Nagar, Ghaziabad 201002, Uttar Pradesh, India.
ACS Appl Mater Interfaces. 2024 Nov 13;16(45):62594-62605. doi: 10.1021/acsami.4c11285. Epub 2024 Oct 29.
The technological advancement of Additive Manufacturing has enabled the fabrication of various customized artifacts and devices, which has prompted a huge demand for multimaterials that can cater to stringent mechanical, chemical, and other functional property requirements. Photocurable formulations that are widely used for Digital Light Processing (DLP)/Stereolithography (SLA) 3D printing applications are now expected to meet these new challenges of hard and soft or stretchable structural requirements in addition to good resolution in multiple scales. Here we present a biocompatible photocurable resin formulation with tunable mechanical properties that can produce hard or stretchable elastomeric 3D printed materials in a graded manner. Acrylate poly(lactic acid) (PLA) grafted polyvinyl acetate (PVAc) polymer was mixed with hydroxyl ethyl methacrylate (HEMA) and hydroxyl ethyl acrylate (HEA) as reactive diluents (50-70 wt %) in various compositions to form a series of photocurable resin formulations. Depending on the nature of the reactive diluent (HEMA or HEA) and their weight percentage, the mechanical properties of the 3D printed parts could be fine-tuned from hard (Tensile strength 20.6 ± 2 MPa, elongation 2 ± 1%) to soft (Tensile strength 1.1 ± 0.2 MPa, elongation 62 ± 8%) materials. The printed materials displayed remarkable dye absorption (95%), showing stimuli-responsive behavior for dye release (with respect to both pH and enzyme), while also demonstrating high cell viability (>90%) for mouse embryonic (WT-MEF) cells and degradability in PBS solution. These biobased 3D printing resins have the potential for a variety of applications, including tissue engineering, soft robotics, dye absorption, and elastomeric actuators.
增材制造的技术进步使得各种定制工件和设备的制造成为可能，这引发了对能够满足严格机械、化学和其他功能特性要求的多种材料的巨大需求。目前，广泛用于数字光处理（DLP）/立体光刻（SLA）3D打印应用的光固化配方，除了要在多个尺度上具有良好分辨率外，还需要满足硬软或可拉伸结构要求的这些新挑战。在此，我们展示了一种具有可调机械性能的生物相容性光固化树脂配方，该配方能够以分级方式生产硬质或可拉伸的弹性体3D打印材料。将丙烯酸酯聚乳酸（PLA）接枝聚醋酸乙烯酯（PVAc）聚合物与甲基丙烯酸羟乙酯（HEMA）和丙烯酸羟乙酯（HEA）作为反应性稀释剂（50 - 70 wt%）以各种组成混合，形成一系列光固化树脂配方。根据反应性稀释剂（HEMA或HEA）的性质及其重量百分比，3D打印部件的机械性能可以从硬质材料（拉伸强度20.6±2 MPa，伸长率2±1%）微调至软质材料（拉伸强度1.1±0.2 MPa，伸长率62±8%）。打印材料表现出显著的染料吸收（95%），显示出对染料释放的刺激响应行为（相对于pH和酶两者），同时还对小鼠胚胎（WT - MEF）细胞表现出高细胞活力（>90%）以及在PBS溶液中的可降解性。这些生物基3D打印树脂具有多种应用潜力，包括组织工程、软体机器人技术、染料吸收和弹性体致动器。
