Medical Research Center, College of Medicine, The Third People's Hospital of Chengdu (Affiliated Hospital of Southwest Jiaotong University, Southwest Jiaotong University, Chengdu, 610031, Sichuan, China.
Department of Urology, The Third People's Hospital of Chengdu, The Affiliated Hospital of Southwest Jiaotong University, Chengdu, 610014, China.
Mol Biomed. 2024 Oct 30;5(1):54. doi: 10.1186/s43556-024-00217-8.
Systemic lupus erythematosus (SLE) is a multifaceted autoimmune disorder characterized by dysregulated immune responses and autoantibody production, which affects multiple organs and varies in clinical presentation and disease severity. The development of SLE is intricate, encompassing dysregulation within the immune system, a collapse of immunological tolerance, genetic susceptibilities to the disease, and a variety of environmental factors that can act as triggers. This review provides a comprehensive discussion of the pathogenesis and treatment strategies of SLE and focuses on the progress and status of traditional and emerging treatment strategies for SLE. Traditional treatment strategies for SLE have mainly employed non-specific approaches, including cytotoxic and immunosuppressive drugs, antimalarials, glucocorticoids, and NSAIDs. These strategies are effective in mitigating the effects of the disease, but they are not a complete cure and are often accompanied by adverse reactions. Emerging targeted therapeutic drugs, on the other hand, aim to control and treat SLE by targeting B and T cells, inhibiting their activation and function, as well as the abnormal activation of the immune system. A deeper understanding of the pathogenesis of SLE and the exploration of new targeted treatment strategies are essential to advance the treatment of this complex autoimmune disease.
系统性红斑狼疮（SLE）是一种多方面的自身免疫性疾病，其特征是免疫反应失调和自身抗体产生，影响多个器官，临床表现和疾病严重程度各异。SLE 的发展很复杂，包括免疫系统的失调、免疫耐受的崩溃、对疾病的遗传易感性以及各种可能作为触发因素的环境因素。本文全面讨论了 SLE 的发病机制和治疗策略，并重点介绍了 SLE 的传统和新兴治疗策略的进展和现状。SLE 的传统治疗策略主要采用非特异性方法，包括细胞毒性和免疫抑制剂、抗疟药、糖皮质激素和 NSAIDs。这些策略在减轻疾病的影响方面是有效的，但它们不是完全治愈的方法，而且常常伴随着不良反应。新兴的靶向治疗药物则通过针对 B 和 T 细胞、抑制其激活和功能以及免疫系统的异常激活来控制和治疗 SLE。深入了解 SLE 的发病机制并探索新的靶向治疗策略对于推进这种复杂的自身免疫性疾病的治疗至关重要。
