Wilson Melissa P, Jankowski Catherine M, Cook Paul F, Kulik Grace L, Iriarte Evelyn, SantaBarbara Nicholas J, Fourman Lindsay T, Erlandson Kristine M
Department of Medicine, Division of Infectious Disease, University of Colorado Denver-Anschutz Medical Campus, 12700 E. 19th Ave., Mail Stop B168, Aurora, CO, 80045, USA.
College of Nursing, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA.
AIDS Behav. 2025 Feb;29(2):535-545. doi: 10.1007/s10461-024-04537-2. Epub 2024 Oct 30.
With earlier initiation and more effective antiretroviral therapy regimens, people with HIV (PWH) are achieving longer lifespans but with high rates of chronic disease and physical function impairment. Regular exercise can reduce disease burden, but older adults with HIV may experience unique barriers to exercise. Exercise self-efficacy (ESE) is an important component of initiation and continuation of exercise, and ESE measurement may illuminate barriers to exercise. Our goal was to evaluate differences in ESE between older PWH and seronegative participants (controls) prior to exercise initiation and over 24-weeks of a supervised resistance and endurance exercise intervention. Virally suppressed PWH and controls completed 12 weeks of moderate-intensity exercise, followed by randomization to 12 weeks of moderate- or high-intensity exercise. The Self-Efficacy for Exercise survey was completed at weeks 0, 12, and 24. Enrolled participants (PWH = 32, controls = 37) had a median age of 56 years [interquartile range: 52, 62]; 63 (91%) were male, and 23 (33%) identified as ethnic or racial minorities. ESE scores differed by serostatus prior to exercise initiation (PWH: 61.3 [95% confidence interval: 54.5, 68]; controls: 73.8 [67.6, 80.1]; p = 0.01; t = - 2.7). ESE scores did not change over the initial 12 weeks in PWH (4.8 [- 2.1, 11.8]; p = 0.17; t = 1.4) or controls (- 2.3 [- 8.9, 4.4]; p = 0.50; t = - 0.7) or between weeks 13 and 24 (pooled serostatus: - 4.8 [- 9.7, 0.2]; p = 0.06: t = - 1.9). Future interventions should incorporate additional strategies to improve ESE, such as text messaging support, coaching, or external rewards.
随着抗逆转录病毒治疗方案的更早启动和更有效实施，感染艾滋病毒的人（PWH）寿命延长，但慢性病和身体功能受损率较高。定期锻炼可以减轻疾病负担，但老年艾滋病毒感染者可能在锻炼方面面临独特障碍。锻炼自我效能感（ESE）是开始和持续锻炼的重要组成部分，测量ESE可能会揭示锻炼的障碍。我们的目标是评估在开始锻炼前以及在为期24周的有监督的抗阻和耐力锻炼干预期间，老年PWH与血清阴性参与者（对照组）在ESE方面的差异。病毒得到抑制的PWH和对照组完成了12周的中等强度锻炼，随后随机分为12周的中等强度或高强度锻炼。在第0、12和24周完成了锻炼自我效能感调查。纳入的参与者（PWH = 32，对照组 = 37）的年龄中位数为56岁[四分位间距：52, 62]；63人（91%）为男性，23人（33%）为少数族裔或种族。在开始锻炼前，ESE得分因血清学状态而异（PWH：61.3[95%置信区间：54.5, 68]；对照组：73.8[67.6, 80.1]；p = 0.01；t = - 2.7）。在最初的12周内，PWH（4.8[- 2.1, 11.8]；p = 0.17；t = 1.4）或对照组（- 2.3[- 8.9, 4.4]；p = 0.50；t = - 0.7）的ESE得分没有变化，在第13周和第24周之间（合并血清学状态：- 4.8[- 9.7, 0.2]；p = 0.06：t = - 1.9）也没有变化。未来的干预措施应纳入其他提高ESE的策略，如短信支持、指导或外部奖励。
