高强度运动改善 HIV 老年感染者的活动限制和训练习惯研究（HEALTH）：研究方案
The High-Intensity Exercise Study to Attenuate Limitations and Train Habits in Older Adults With HIV (HEALTH): A Research Protocol.
机构信息
Vitor H. F. Oliveira, PhD, is an Acting Instructor, University of Washington, School of Nursing, Seattle, Washington, USA. Kristine M. Erlandson, MD, MS, is an Associate Professor, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA. Paul F. Cook, PhD, is an Associate Professor, University of Colorado College of Nursing, Anschutz Medical Campus, Aurora, Colorado, USA. Catherine Jankowski, PhD, is an Associate Professor, University of Colorado College of Nursing, Anschutz Medical Campus, Aurora, Colorado, USA. Samantha MaWhinney, ScD, is a Professor, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA. Sahera Dirajlal-Fargo, DO, MS, is an Assistant Professor, Rainbow Babies and Children's Hospital, Case Western Reserve University, Cleveland, Ohio, USA. Leslie Knaub, MS, is a Senior Professional Research Assistant, University of Colorado Anschutz Medical Campus, Rocky Mountain Regional VA Medical Center, Aurora, Colorado, USA. Chao-Pin Hsiao, RN, PhD, FAAN, is an Assistant Professor, Frances Payne Bolton School of Nursing, Case Western Reserve University, Cleveland, Ohio, USA. Christine Horvat Davey, RN, PhD, is a Research Associate and Postdoctoral Fellow, Frances Payne Bolton School of Nursing, Case Western Reserve University, Cleveland, Ohio, USA. Allison R. Webel, RN, PhD, FAAN, is a Professor and Associate Dean for Research, University of Washington, School of Nursing, Seattle, Washington, USA.
出版信息
J Assoc Nurses AIDS Care. 2022;33(2):178-188. doi: 10.1097/JNC.0000000000000276.
The High-Intensity Exercise Study to Attenuate Limitations and Train Habits in Older Adults With HIV (HEALTH), which incorporates an exercise and biobehavioral coaching intervention, has the following overall goals: (a) to determine whether high-intensity interval training (HIIT) mitigates physical function impairments, fatigue, and impairments in mitochondrial bioenergetics of older people living with HIV (PLWH) to a greater extent than continuous moderate exercise (CME); and (b) to determine whether a biobehavioral coaching and mobile health text messaging intervention after HIIT or CME can promote long-term adherence to physical activity. The HEALTH study is a randomized trial of 100 older PLWH (≥50 years of age) who self-report fatigue and have a sedentary lifestyle. Enrolled participants will be randomized to 16 weeks of supervised HIIT or CME training, followed by a 12-week maintenance phase, involving a mobile health coaching intervention. Outcomes of the HEALTH study will inform the development of scalable, effective exercise recommendations tailored to the unique needs of aging PLWH.
高强度运动改善老年 HIV 感染者的体能限制和训练习惯研究（HEALTH），其中包含运动和生物行为训练干预，具有以下总体目标：(a) 确定高强度间歇训练（HIIT）是否比持续中等强度运动（CME）更能减轻老年 HIV 感染者（PLWH）的身体功能障碍、疲劳和线粒体生物能障碍；以及 (b) 确定 HIIT 或 CME 后进行生物行为训练和移动健康短信干预是否能促进长期坚持身体活动。HEALTH 研究是一项针对 100 名年龄在 50 岁及以上、报告有疲劳感且生活方式久坐不动的老年 PLWH 的随机试验。入组参与者将被随机分配到 16 周的监督 HIIT 或 CME 训练，然后是 12 周的维持期，包括移动健康训练干预。HEALTH 研究的结果将为制定针对老年 PLWH 独特需求的可扩展、有效的运动建议提供信息。
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